Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Proteases >Gamma-secretase inhibitors >Semagacestat

Semagacestat

Semagacestat Structure
  • ₹0
  • Product name: Semagacestat
  • CAS: 425386-60-3
  • MF: C19H27N3O4
  • MW: 361.44
  • EINECS:1592732-453-0
  • MDL Number:MFCD09970409
  • Synonyms:(2S)-2-HYDROXY-3-METHYL-N-[(2S)-1-{[(1S)-3-METHYL-2-OXO-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPIN-1-YL]AMINO}-1-OXOPROPAN-2-YL]BUTANAMIDE;semagacestat;Butanamide, 2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5- tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-, (2S)-;(2S)-2-Hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]butanamide;Semagacestat/LY-450139;Unii-3yn0602W4w;LY450139(Semagacestat);2-hydroxy-3-Methyl-N-[(1S)-1-Methyl-2-oxo-2-[[(1S)-2
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :208-212 °C
Boiling point :681.9±55.0 °C(Predicted)
Density :1.22
Flash point :366.2℃
storage temp. :2-8°C
solubility :DMSO (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
form :Solid
pka :12.97±0.20(Predicted)
color :White

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. Semagacestat is a potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively. It also blocks Notch signaling (IC50 = 14.1 nM). Semagacestat modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion. Although semagacestat does not improve cognitive status in humans, it is useful as a pan γ-secretase inhibitor for research purposes.

More related product prices

p-Hydroxybenzaldehyde 10-Hydroxycamptothecin Methyl acrylate Methylparaben Glycolic acid CHLOROPHOSPHONAZO III Kresoxim-methyl Parathion-methyl Glycolonitrile Butyramide Methyl bromide

Related product price

Suppliers and manufacturers

A.J Chemicals CLEARSYNTH LABS LTD.
Capot Chemical Co.,Ltd.
CONIER CHEM AND PHARMA LIMITED
Zhengzhou Alfa Chemical Co.,Ltd
Career Henan Chemica Co
Dayang Chem (Hangzhou) Co.,Ltd.
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
TargetMol Chemicals Inc.