storage temp. :Store at -20°C solubility :DMSO: 3 mg/ml; DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml form :A crystalline solid color :Off-white to light yellow
Safety Information
Symbol(GHS):
Signal word:
Warning
Hazard statements:
Code
Hazard statements
Hazard class
Category
Signal word
Pictogram
P-Codes
H302
Harmful if swallowed
Acute toxicity,oral
Category 4
Warning
P264, P270, P301+P312, P330, P501
H315
Causes skin irritation
Skin corrosion/irritation
Category 2
Warning
P264, P280, P302+P352, P321,P332+P313, P362
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Category 2A
Warning
P264, P280, P305+P351+P338,P337+P313P
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure;Respiratory tract irritation
Category 3
Warning
Precautionary statements:
P261
Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
Sirtuins (SIRTs) represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs). SIRT2 deacetylates histone H4 and α-tubulin and functions as a regulator of cell cycle progression, a determinant of myelination, a modulator of autophagy, and a suppressor of brain inflammation. SirReal2 is an aminothiazole that acts as a SIRT-rearranging ligand to selectively inhibit SIRT2 (IC50 = 140 nM). SirReal2 is >1,000-fold more potent at inhibiting the activity of SIRT2 than that of SIRT1 or SIRT3-6. This compound has been shown to be active in HeLa cells by significantly increasing α-tubulin acetylation.
