Sugammadex sodium
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- ₹0
- Product name: Sugammadex sodium
- CAS: 343306-79-6
- MF: C72H104Na8O48S8
- MW: 2177.97
- EINECS:200-838-9
- MDL Number:MFCD09954145
- Synonyms:ORG-25969/SugaMMadex;Sugammadex IMP;US-DMF No.: 033904 ASMF filed;6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,...;Sugammadex sodium (Org-25969);6 Sugammadex Sodium;Glucose-sodium;Sulgeng glucose sodium
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Properties
storage temp. :Inert atmosphere,Room Temperature
solubility :DMF: 2.5 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
form :A crystalline solid
color :White to off-white
InChIKey :NIOBYNJFPSIMJF-OBHNVPISNA-N
solubility :DMF: 2.5 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
form :A crystalline solid
color :White to off-white
InChIKey :NIOBYNJFPSIMJF-OBHNVPISNA-N
Safety Information
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Description
To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.Related product price
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