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ChemicalBook > Product Catalogue >API >Nervous system drugs >Drug Metabolism in Human Brain >Entacapone

Entacapone

Entacapone Structure
  • ₹7707.4 - ₹25958.35
  • Product name: Entacapone
  • CAS: 130929-57-6
  • MF: C14H15N3O5
  • MW: 305.29
  • EINECS:212-686-0
  • MDL Number:MFCD00866580
  • Synonyms:(E)-2-Cyano-3-(3，4-dihydroxy-5-nitrophenyl)-N，N-diethyl-2-pmpenamide;Entacapone (150 mg);(2E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enaMide;2-PropenaMide,2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2E)-;Entacapone (isomer E);(E)-2-cyano-3-(5-(dihydroxyamino)-3,4-dioxocyclohexa-1,5-dienyl)-N,N-diethylacrylamide;ENTACAPONE;2-cyano-3-(5-dihydroxyamino-3,4-dioxo-1-cyclohexa-1,5-dienyl)-n,n-diethyl-prop-2-enamide
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0654
  • Product descriptionEntacapone ≥98% (HPLC)
  • Packaging10MG
  • Price₹7707.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0654
  • Product descriptionEntacapone ≥98% (HPLC)
  • Packaging50MG
  • Price₹25958.35
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0654 Entacapone ≥98% (HPLC) 10MG ₹7707.4 2022-06-14 Buy
Sigma-Aldrich(India) SML0654 Entacapone ≥98% (HPLC) 50MG ₹25958.35 2022-06-14 Buy

Properties

Melting point :162-1630C
Boiling point :526.6±50.0 °C(Predicted)
Density :1.392±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble20mg/mL, clear
form :powder
pka :pKa ~4.5(at 25℃)
color :white to light brown
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :JRURYQJSLYLRLN-BJMVGYQFSA-N
CAS DataBase Reference :130929-57-6(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.

Description

Catechol O-methyltransferase (COMT) is a key enzyme involved in the degradation of catecholamines including dopamine, epinephrine, and norepinephrine. COMPT metabolizes L-3,4-dihydroxyphenylalanine (L-DOPA) to 3-O-methyldopa (3-OMD), and then further to vanillactic acid, which is excreted in urine. Entacapone is a peripherally acting, selective and reversible COMT inhibitor with IC50 values of 150-300 nM in rat liver (Ki = 145 nM) and 10-20 nM in rat brain tissues. It was designed as an adjuvant to L-DOPA/dopa decarboxylase inhibitor treatment for Parkinson’s disease. Peripheral COMT inhibition with entacapone can decrease 3-OMD levels in the rat brain by 16-52% and prolong the bioavailability of L-DOPA in patients with Parkinson’s disease.

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Suppliers and manufacturers

Chemicea Pharmaceuticals Pvt Ltd USV Pvt Ltd Aurobindo Pharma Limited Arch Pharmalabs Ltd Ramdev Chemicals Pvt Ltd Besil Chem LLP Ralington Pharma Cohance Lifesciences (Previously RA Chem Pharma Ltd) Vishrudh laboratories pvt ltd Vijaya Pharma And Life Science