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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antiviral drugs >Entecavir hydrate

Entecavir hydrate

Entecavir hydrate Structure
  • ₹8500 - ₹29500
  • Product name: Entecavir hydrate
  • CAS: 209216-23-9
  • MF: C12H17N5O4
  • MW: 295.3
  • EINECS:606-668-5
  • MDL Number:MFCD09754448
  • Synonyms:entecavir hydrate;ENTECAVIR MONOHYDRATE;2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate;Entecavir hydrate / 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate;2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate ,99.9%;2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]-6H-purin-6-one monohydrate ,99.7%;Entecavir Monohydrate IsoMers;2-aMino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxyMethyl)-2-Methylidenecyclopentyl]-6,9-dihydro-3H-purin-6-one
2 prices
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Brand

  • TCI Chemicals (India)

Package

  • 50MG
  • 200MG
  • ManufacturerTCI Chemicals (India)
  • Product numberE0899
  • Product descriptionEntecavir Monohydrate
  • Packaging50MG
  • Price₹8500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberE0899
  • Product descriptionEntecavir Monohydrate
  • Packaging200MG
  • Price₹29500
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) E0899 Entecavir Monohydrate 50MG ₹8500 2022-05-26 Buy
TCI Chemicals (India) E0899 Entecavir Monohydrate 200MG ₹29500 2022-05-26 Buy

Properties

Melting point :>220°
alpha :D +35.0° (c = 0.38 in water)
Density :1.81
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Sparingly), Water (Slightly, Heated, Sonicated)
form :Solid
color :White to Off-White
Merck :14,3595
CAS DataBase Reference :209216-23-9(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Entecavir is a potent deoxyguanosine nucleoside analog with antiviral activity selective for hepadnaviruses (EC50 = 3.7 nM against the hepatitis B virus (HBV) in cultured 2.2.15 liver cells). In vitro, the active intracellular form of entecavir, entecavir triphosphate, demonstrates a higher binding affinity for HBV DNA polymerase than the natural guanosine triphosphate substrate and effectively inhibits HBV DNA replication at 3 stages in the replication pathway: priming, reverse transcription, and DNA-dependent DNA synthesis. The potential therapeutic bene?ts of entecavir have been demonstrated in woodchuck and duck models of HBV. Activity was con?rmed in phase I/II preclinical studies and entecavir received approval from the U.S. Food and Drug Administration for the treatment of adults with chronic hepatitis B.

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