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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Sulfonamides and synergist >Sulfasalazine

Sulfasalazine

Sulfasalazine Structure
  • ₹7700 - ₹35105.48
  • Product name: Sulfasalazine
  • CAS: 599-79-1
  • MF: C18H14N4O5S
  • MW: 398.39
  • EINECS:209-974-3
  • MDL Number:MFCD00057363
  • Synonyms:SULFASALAZINE;LABOTEST-BB LT00772281;5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid;5-[4-(2-PYRIDYLSULFAMOYL)PHENYLAZO]SALICYLIC ACID;Benzoic acid, 2-hydroxy-5-4-(2-pyridinylamino)sulfonylphenylazo-;SULFASALAZINE USP 26,EP 4;SULFASALAZINE(SASP)(NDC:55631-0130);SALICYLAZOSULPHAPYRIDINE
4 prices
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Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)

Package

  • 10G
  • 25G
  • 50G
  • 100G
  • ManufacturerSigma-Aldrich(India)
  • Product numberS0883
  • Product descriptionSulfasalazine 97.0-101.5%
  • Packaging10G
  • Price₹8638.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS0883
  • Product descriptionSulfasalazine 97.0-101.5%
  • Packaging50G
  • Price₹21455.15
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS0883
  • Product descriptionSulfasalazine 97.0-101.5%
  • Packaging100G
  • Price₹35105.48
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberS0580
  • Product descriptionSulfasalazine
  • Packaging25G
  • Price₹7700
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) S0883 Sulfasalazine 97.0-101.5% 10G ₹8638.35 2022-06-14 Buy
Sigma-Aldrich(India) S0883 Sulfasalazine 97.0-101.5% 50G ₹21455.15 2022-06-14 Buy
Sigma-Aldrich(India) S0883 Sulfasalazine 97.0-101.5% 100G ₹35105.48 2022-06-14 Buy
TCI Chemicals (India) S0580 Sulfasalazine 25G ₹7700 2022-05-26 Buy

Properties

Melting point :260-265 °C (dec.)(lit.)
Boiling point :689.3±65.0 °C(Predicted)
Density :1.3742 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :NH4OH 1 M: 50 mg/mL, clear, red
pka :pKa 0.6(H2O t = 20 I < 0.001) (Uncertain);2.4(H2O t = 20 I < 0.001) (Uncertain);9.7(H2O t = 20 I < 0.001) (Uncertain);11.8(H2O t = 20 I < 0.001) (Uncertain)
form :powder
color :Orange
Water Solubility :<0.1 g/100 mL at 25 ºC
Merck :14,8942
BRN :356241
BCS Class :2,4
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
InChIKey :NCEXYHBECQHGNR-QZQOTICOSA-N
CAS DataBase Reference :599-79-1(CAS DataBase Reference)
IARC :2B (Vol. 108) 2016
EPA Substance Registry System :Salicylazosulfapyridine (599-79-1)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P284 Wear respiratory protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.

Description

Sulfasalazine is a prodrug of the anti-inflammatory agent 5-aminosalicylic acid that is covalently linked to the antibiotic sulfapyridine by an azo bond. This bond is rapidly cleaved by bacteria in the terminal ileum and colon, thus releasing the active anti-inflammatory component. It has long been used in treatment of inflammatory bowel disease and rheumatoid arthritis because of its ability to induce T lymphocyte apoptosis, modulate inflammatory mediators from both cyclooxygenase/5-lipoxygenase pathways and NF-κB signaling pathways, attenuate transcription of proinflammatory cytokines, and activate PPARγ.

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