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ChemicalBook > Product Catalogue >API >Specialty drugs >Antidote >TACRINE HYDROCHLORIDE

TACRINE HYDROCHLORIDE

TACRINE HYDROCHLORIDE Structure
  • ₹0
  • Product name: TACRINE HYDROCHLORIDE
  • CAS: 1684-40-8
  • MF: C13H15ClN2
  • MW: 234.72
  • EINECS:216-867-5
  • MDL Number:MFCD00012657
  • Synonyms:1,2,3,4-tetrahydro-9-acridinaminmonohydrochloride ;1,2,3,4-tetrahydro-9-aminoacridinehydrochloride ;1,2,3,4-tetrahydro-9-amino-acridinmonohydrochloride ;9-amino-1,2,3,4-tetrahydro-acridinhydrochloride ;tacrine monohydrochloride;1,2,3,4-TETRAHYDRO-9-ACRYDINAMINEHCLMONOHYDRATE;1,2,3,4-TETRAHYDRO-9-ACRIDINAMINEHYDROCHLORIDEMONOHYDRATE;1,2,3,4-Tetrahydro-9-Acridinamine Hydrochloride Dihydrate
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :280-284 °C(lit.)
storage temp. :Inert atmosphere,2-8°C
solubility :Soluble in aqueous buffers
pka :pKa 9.8 (Uncertain)
form :Crystalline solid
color :White to light yellow
CAS DataBase Reference :1684-40-8(CAS DataBase Reference)
EPA Substance Registry System :Tacrine hydrochloride (1684-40-8)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger GHS hazard pictograms P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

Description

Tacrine is a derivative of aminoacridine which functions as an inhibitor of both AChE and butyrylcholinesterase. It has been used clinically in the treatment of Alzheimer’s disease. Tacrine also inhibits the uptake of serotonin and noradrenaline in rat cerebral cortex and decreases depolarization-induced calcium influx through L-type calcium channels in SN56 neuronal cells.

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