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THROMBIN

THROMBIN Structure
  • ₹34998.3
  • Product name: THROMBIN
  • CAS: 581-64-6
  • MF: C12H10ClN3S
  • MW: 263.74
  • EINECS:209-470-3
  • MDL Number:MFCD00082072
  • Synonyms:thionin,thionine,thionine chloride,3,7-diaminophenothiazin-5-ium chloride,7-amino-3-imino-3h-phenothiazine hydrochloride,c.i. 52000;COAGULATION FACTOR ILA;COAGULATION FACTOR FLA;EC 3.4.21.5;EC: 3.4.21.5;FIBRINOGENASE;FACTOR IIA;3,7-diaminophenothiazin-5-ium chloride
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Brand

  • Sigma-Aldrich(India)

Package

  • 150UNITS
  • ManufacturerSigma-Aldrich(India)
  • Product numberT9326
  • Product descriptionThrombin human BioUltra, recombinant, expressed in HEK 293 cells, aqueous solution, ≥95% (SDS-PAGE)
  • Packaging150UNITS
  • Price₹34998.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T9326 Thrombin human BioUltra, recombinant, expressed in HEK 293 cells, aqueous solution, ≥95% (SDS-PAGE) 150UNITS ₹34998.3 2022-06-14 Buy

Properties

storage temp. :−20°C
solubility :H2O: 1 mL/vial clear to slightly hazy, colorless solution
Colour Index :52000
form :powder
color :white
Merck :9346
CAS DataBase Reference :581-64-6(CAS DataBase Reference)
EPA Substance Registry System :Thionin (581-64-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P363 Wash contaminated clothing before reuse.
P501 Dispose of contents/container to..…

Description

Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin and potentiates the procoagulation process by activating factors V, VIII, XI, and XIII. Conversely, thrombin aids the anticoagulant process by activating protein C. Activated protein C inhibits activated factors V and VIII ultimately down-regulating further thrombin production. Thrombin is often used as a potent platelet activator in vitro. Platelet responses to thrombin are mediated through protease-activated receptors (PARs). Thrombin-mediated signaling regulates a diverse range of metabolic processes including activation of phospholipases in platelets, endothelial cells, and cardiac myocytes.

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