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TRYPTANTHRIN

TRYPTANTHRIN Structure
  • ₹8021.33 - ₹31987.88
  • Product name: TRYPTANTHRIN
  • CAS: 13220-57-0
  • MF: C15H8N2O2
  • MW: 248.24
  • EINECS:
  • MDL Number:MFCD00012073
  • Synonyms:TRYPTANTHRIN;tryptanthrine ;6,12-Dihydroindolo[2,1-b]quinazoline-6,12-dione;Trypanthrine;NSC 349447;CouroupitineAIndolo(2,1-b)quinazoline-6,12-dioneTryptanthrine;TRYPTANTHRIN-D4;INDOLO[2,1-B]QUINAZOLINE-6,12-DIONE
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0310
  • Product descriptionTryptanthrin ≥98% (HPLC)
  • Packaging5MG
  • Price₹8021.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0310
  • Product descriptionTryptanthrin ≥98% (HPLC)
  • Packaging25MG
  • Price₹31987.88
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0310 Tryptanthrin ≥98% (HPLC) 5MG ₹8021.33 2022-06-14 Buy
Sigma-Aldrich(India) SML0310 Tryptanthrin ≥98% (HPLC) 25MG ₹31987.88 2022-06-14 Buy

Properties

Melting point :258 °C(Solv: ethanol (64-17-5))
Boiling point :469.3±28.0 °C(Predicted)
Density :1.45±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble2mg/mL (warmed)
pka :-3.06±0.20(Predicted)
form :powder
color :faint yellow to dark yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :VQQVWGVXDIPORV-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:

Description

Tryptanthrin is an alkaloid tryptophan derivative originally isolated from various plants and found to have antimicrobial actions. Among its many actions in cells, it inhibits both 5-lipoxygenase and cyclooxygenase-2 (IC50s = 600 and 64 nM, respectively). Tryptanthrin suppresses angiogenesis in vivo and blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro. It also prevents ERK signaling through Nrf2, reducing oxidative stress-induced hepatocytotoxicity.

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