Tariquidar
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- ₹13791.05 - ₹55727.1
- Product name: Tariquidar
- CAS: 206873-63-4
- MF: C38H38N4O6
- MW: 646.73
- EINECS:
- MDL Number:MFCD09837824
- Synonyms:N-[2-[[[4-[2-(3,4-Dihydro-6,7-diMethoxy-isoquinolin-2(1H)-yl)ethyl]phenyl]aMino]carbonyl]-4,5-diMethoxyphenyl]-3-quinolinecarboxaMide;N-[2-({4-[2-(6,7-diMethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]phenyl}carbaMoyl)-4,5-diMethoxyphenyl]quinoline-3-carboxaMide;N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide Tariquidar;Tariquidar N-[2-[[4-[2-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide;Tariquidar, >=98%;XL9576 Free base;N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxy-phenyl]quinoline-3-carboxamide;Tariquidar
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML1790
- Product descriptionTariquidar ≥98% (HPLC)
- Packaging5MG
- Price₹13791.05
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML1790
- Product descriptionTariquidar ≥98% (HPLC)
- Packaging25MG
- Price₹55727.1
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML1790 | Tariquidar ≥98% (HPLC) | 5MG | ₹13791.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1790 | Tariquidar ≥98% (HPLC) | 25MG | ₹55727.1 | 2022-06-14 | Buy |
Properties
Melting point :>190oC (dec.)
Boiling point :716.0±60.0 °C(Predicted)
Density :1.276±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :10.67±0.70(Predicted)
form :powder
color :white to light brown
Boiling point :716.0±60.0 °C(Predicted)
Density :1.276±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :10.67±0.70(Predicted)
form :powder
color :white to light brown
Safety Information
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Description
Tariquidar is an anthranilic acid derivative that binds to P-glycoprotein (Kd = 5.1 nM) and inhibits transport activity. It inhibits transport of vinblastine and paclitaxel in multidrug resistant CHrB30 cells, increasing the steady state accumulation to non-P-glycoprotein-expressing multidrug sensitive cell levels (EC50 = 487 nM). Tariquidar also enhances the distribution of its substrates, increasing the amount of substrate entering the CNS. When administered at doses of 2 and 6.25 mg/kg in mice in combination with the peripherally-restricted opioid loperamide, the latency to paw withdrawal in a hot plate assay increases, indicating that loperamide is transported into the CNS.Related product price
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