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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >AC480 (BMS-599626)

AC480 (BMS-599626)

AC480 (BMS-599626) Structure
  • ₹7700 - ₹22000
  • Product name: AC480 (BMS-599626)
  • CAS: 714971-09-2
  • MF: C27H27FN8O3
  • MW: 530.55
  • EINECS:
  • MDL Number:MFCD10565678
  • Synonyms:Carbamic acid, [4-[[1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl]amino]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]-, (3S)-3-morpholinylmethyl ester (9CI);AC-480;N-[4-[[1-[(3-Fluorophenyl)Methyl]-1H-indazol-5-yl]aMino]-5-Methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbaMic Acid (3S)-3-MorpholinylMethyl Ester;(S)-Morpholin-3-ylmethyl (4-((1-(3-fluorobenzyl)-1H-indazol-5-yl)amino)-5-methylpyrrolo[2,1-f][1,;AC480 (BMS-599626);(S)-morpholin-3-ylmethyl 4-(1-(3-fluorobenzyl)-1H-indazol-5-ylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazin-6-ylcarbamate;(3S)-morpholin-3-ylmethyl N-[4-({1-[(3-fluorophenyl)methyl]-1H-indazol-5-yl}amino)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]carbamate;[(3S)-Morpholin-3-yl]methyl N-[4-[[1-[(3-fluorophenyl)methyl]indazol-5-yl]amino]-5-methyl-pyrrolo
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • TCI Chemicals (India)

Package

  • 10MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB5520
  • Product descriptionBMS-599626
  • Packaging10MG
  • Price₹7700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB5520
  • Product descriptionBMS-599626
  • Packaging50MG
  • Price₹22000
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B5520 BMS-599626 10MG ₹7700 2022-05-26 Buy
TCI Chemicals (India) B5520 BMS-599626 50MG ₹22000 2022-05-26 Buy

Properties

Density :1.48±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥28.35 mg/mL in DMSO
form :powder to crystal
pka :7.27±0.46(Predicted)
color :White to Light yellow to Light orange
CAS DataBase Reference :714971-09-2

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

It is a highly selective and potent inhibitor of HER1 and HER2 kinases and inhibits tumor cell proliferation through modulation of receptor signaling. BMS-599626 inhibits HER1/HER2 receptor heterodimerization and provides an additional mechanism of inhibiting tumors in which receptor coexpression and heterodimerization play a major role in driving tumor growth.

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