Torin 1
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- ₹32230
- Product name: Torin 1
- CAS: 1222998-36-8
- MF: C35H28F3N5O2
- MW: 607.62
- EINECS:
- MDL Number:MFCD18782653
- Synonyms:1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-[4-(4-PROPANOYLPIPERAZIN-1-YL)-3-(TRIFLUOROMETHYL)PHENYL]-9-QUINOLIN-3-YLBENZO[H][1,6]NAPHTHYRIDIN-2-ONE;Torin 1;Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-;1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one Torin 1;Torin 1 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one;1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one;Torin 1, >=98%
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number475991
- Product descriptionmTOR Inhibitor XI, Torin1 - Calbiochem mTOR Inhibitor XI, Torin1, CAS 1222998-36-8, is a cell-permeable, highly potent, ATP-competitive inhibitor of mTOR and DNA-PK (IC50 = 4.32 and 6.34 nM
- Packaging10MG
- Price₹32230
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 475991 | mTOR Inhibitor XI, Torin1 - Calbiochem mTOR Inhibitor XI, Torin1, CAS 1222998-36-8, is a cell-permeable, highly potent, ATP-competitive inhibitor of mTOR and DNA-PK (IC50 = 4.32 and 6.34 nM | 10MG | ₹32230 | 2022-06-14 | Buy |
Properties
Melting point :>223°C (dec.)
Boiling point :817.2±65.0 °C(Predicted)
Density :1.362
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 8 mg/ml).
form :Yellowish-white powder
pka :4.19±0.20(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Boiling point :817.2±65.0 °C(Predicted)
Density :1.362
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to 8 mg/ml).
form :Yellowish-white powder
pka :4.19±0.20(Predicted)
color :White or off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
Torin 1 is a potent and selective inhibitor of mTOR (IC50 = 2 and 10 nM for mTORC1 and mTORC2, respectively). It shows over 100-fold selectivity for mTOR over PI3Kα and other PI3K-like kinases, including ATM, DNA-PK, and hVps34, as well as 450 other protein kinases. Torin 1, is efficacious at a dose of 20 mg/kg in inhibiting downstream effectors of mTOR in mice.Related product price
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![1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one](https://img.chemicalbook.com/ProductImageEN/2018-12/small/a8d9b725-3501-41e9-8ab0-ffa7fdbdccca.jpg){kind=small}