Name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
Brand: chemicalbook
SKU: 958852-01-2

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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione

₹12308.03 - ₹49437.78
Product name: 5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione
CAS: 958852-01-2
MF: C18H11N3O2S
MW: 333.36
EINECS:
MDL Number:MFCD18074517
Synonyms:5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidenedione;GSK 1059615;(5Z)-5-[[4-(4-Pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione;GSK 1059615 SodiuM Salt Hydrate;SK1059615;(5Z)-5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione sodium salt hydrate;GSK-615;GSK1059615;GSK 1059615; GSK-1059615

Price2 Properties Safety Information Description

2 prices

Selected condition：

Brand

Sigma-Aldrich(India)

Package

10MG
50MG

ManufacturerSigma-Aldrich(India)
Product numberSML0083
Product descriptionGSK 1059615 sodium salt hydrate
Packaging50MG
Price₹49437.78
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberSML0083
Product descriptionGSK 1059615 sodium salt hydrate
Packaging10MG
Price₹12308.03
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0083	GSK 1059615 sodium salt hydrate	50MG	₹49437.78	2022-06-14	Buy
Sigma-Aldrich(India)	SML0083	GSK 1059615 sodium salt hydrate	10MG	₹12308.03	2022-06-14	Buy

Properties

Melting point :>290°C (dec.)
storage temp. :Store at +4°C
solubility :H2O: ≥8mg/mL
form :powder
color :yellow

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PI 3-kinase α (PI3Kα) is a critical regulator of cell growth and transformation. Its signaling pathway is the most commonly mutated pathway in human cancers. GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM) and the common activating mutants of p110α (E542K, E545K, and H1047R) found in cancer. It prevents proliferation in BT474 tumor xenografts and reduces MAPK signaling following twice daily dosing at 25 mg/kg.

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