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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Hormonal antineoplastic drugs >Tamoxifen citrate

Tamoxifen citrate

Tamoxifen citrate Structure
  • ₹5880 - ₹128709.25
  • Product name: Tamoxifen citrate
  • CAS: 54965-24-1
  • MF: C32H37NO8
  • MW: 563.64
  • EINECS:259-415-2
  • MDL Number:MFCD00058321
  • Synonyms:TAMOXIPHEN;Ethanamine, 2-4-(1Z)-1,2-diphenyl-1-butenylphenoxy-N,N-dimethyl-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1);TAMOXIFENCITRATE,USP;TAMOXIFEN CITRATE ANTI-ESTROGEN, PROTEI;TomixipheneCitrate;(Z)-1-(4-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene Citrate;(Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine, citrate (1:1);(Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethylamine citrate (1:1)
5 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 400μL
  • 100MG
  • 300MG
  • 1G
  • 5G
  • ManufacturerSigma-Aldrich(India)
  • Product number579000
  • Product descriptionTamoxifen Citrate - CAS 54965-24-1 - Calbiochem Tamoxifen is a potent synthetic anti-estrogenic agent.
  • Packaging100MG
  • Price₹5880
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2706
  • Product descriptionTamoxifen Citrate Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 300?mg
  • Packaging300MG
  • Price₹17038.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT9262
  • Product descriptionTamoxifen citrate salt ≥99%
  • Packaging1G
  • Price₹39056.6
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT9262
  • Product descriptionTamoxifen citrate salt ≥99%
  • Packaging5G
  • Price₹128709.25
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSAB1305470
  • Product descriptionANTI-TMX1(C-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution
  • Packaging400μL
  • Price₹47796.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 579000 Tamoxifen Citrate - CAS 54965-24-1 - Calbiochem Tamoxifen is a potent synthetic anti-estrogenic agent. 100MG ₹5880 2022-06-14 Buy
Sigma-Aldrich(India) PHR2706 Tamoxifen Citrate Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 300?mg 300MG ₹17038.55 2022-06-14 Buy
Sigma-Aldrich(India) T9262 Tamoxifen citrate salt ≥99% 1G ₹39056.6 2022-06-14 Buy
Sigma-Aldrich(India) T9262 Tamoxifen citrate salt ≥99% 5G ₹128709.25 2022-06-14 Buy
Sigma-Aldrich(India) SAB1305470 ANTI-TMX1(C-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 400μL ₹47796.6 2022-06-14 Buy

Properties

Melting point :140-144 °C
storage temp. :2-8°C
solubility :methanol: soluble50mg/mL, clear, colorless
form :Powder
color :White to off-white
Water Solubility :slightly soluble
Sensitive :Light Sensitive & Hygroscopic
Merck :14,9048
BCS Class :1
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChIKey :FQZYTYWMLGAPFJ-OQKDUQJOSA-N
SMILES :C(/C1=CC=CC=C1)(\C1C=CC(OCCN(C)C)=CC=1)=C(/CC)\C1=CC=CC=C1.C(O)(C(=O)O)(CC(=O)O)CC(=O)O
CAS DataBase Reference :54965-24-1(CAS DataBase Reference)
EPA Substance Registry System :Tamoxifen citrate (54965-24-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Tamoxifen (TMX) is a selective estrogen receptor (ER) modulator used as adjuvant therapy for estrogen-dependent breast cancer. TMX treatment serves to increase ER activity in bone, uterus, and the cardiovasculature system as it decreases ER activity in breast tissues. TMX is metabolized by cytochrome P450 (CYP450) enzymes to the active metabolites N-desmethyl-TMX, 4-hydroxy-N-desmethyl-TMX (endoxifen), and 4-hydroxy-TMX, indicating that certain CYP450 isoforms may be crucial for some of the effects of TMX. In addition, TMX binds microsomal antiestrogen binding sites, altering cholesterol esterification at therapeutic doses and impacting breast cancer cell differentiation, apoptosis, and autophagy.

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