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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Hormonal antineoplastic drugs >Tamoxifen

Tamoxifen

Tamoxifen Structure
  • ₹5260.95 - ₹97998.73
  • Product name: Tamoxifen
  • CAS: 10540-29-1
  • MF: C26H29NO
  • MW: 371.51
  • EINECS:234-118-0
  • MDL Number:MFCD00010454
  • Synonyms:(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine;2-[4-[(Z)-1,2-Di(phenyl)but-1-enyl]phenoxy]-N,N-dimethylethanamine;2-[4-[(Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine;2-[p-[(Z)-1,2-Diphenyl-1-butenyl]phenyloxy]-N,N-dimethylethanamine;N,N-Dimethyl-2-[p-[(Z)-1,2-diphenyl-1-butenyl]phenoxy]ethanamine;C07108;Tamoxifen,(Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene, trans-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethylamine;1-p-β-DiMethylaMinoethoxyphenyl-trans-1,2-diphenylbut-1-ene
6 prices
Selected condition:

Brand

  • Sigma-Aldrich
  • Sigma-Aldrich(India)

Package

  • 50MG
  • 1G
  • 1ML
  • 5G
  • ManufacturerSigma-Aldrich
  • Product number06734
  • Product descriptionTamoxifen certified reference material, TraceCERT?
  • Packaging50MG
  • Price₹8844.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number85256
  • Product descriptionTamoxifen analytical standard
  • Packaging50MG
  • Price₹5260.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number06734
  • Product descriptionTamoxifen certified reference material, TraceCERT?
  • Packaging50MG
  • Price₹8844.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT-143
  • Product descriptionTamoxifen solution 1?mg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant?
  • Packaging1ML
  • Price₹12156.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT5648
  • Product descriptionTamoxifen ≥99%
  • Packaging1G
  • Price₹28480.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT5648
  • Product descriptionTamoxifen ≥99%
  • Packaging5G
  • Price₹97998.73
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich 06734 Tamoxifen certified reference material, TraceCERT? 50MG ₹8844.03 2022-06-14 Buy
Sigma-Aldrich(India) 85256 Tamoxifen analytical standard 50MG ₹5260.95 2022-06-14 Buy
Sigma-Aldrich(India) 06734 Tamoxifen certified reference material, TraceCERT? 50MG ₹8844.03 2022-06-14 Buy
Sigma-Aldrich(India) T-143 Tamoxifen solution 1?mg/mL in methanol, certified reference material, ampule of 1?mL, Cerilliant? 1ML ₹12156.2 2022-06-14 Buy
Sigma-Aldrich(India) T5648 Tamoxifen ≥99% 1G ₹28480.58 2022-06-14 Buy
Sigma-Aldrich(India) T5648 Tamoxifen ≥99% 5G ₹97998.73 2022-06-14 Buy

Properties

Melting point :97-98 °C(lit.)
Boiling point :501.18°C (rough estimate)
Density :1.0630 (rough estimate)
vapor pressure :0Pa at 25℃
refractive index :1.6000 (estimate)
storage temp. :2-8°C
solubility :H2O: insoluble <0.1% at 20°C
form :Solid
pka :pKa 8.71(H2O t = 25 I = 0.025) (Uncertain)
color :Crystals from pet ether
Water Solubility :Insoluble in water. Soluble in methanol, ethanol, propanol or propylene glycol.Soluble in dimethyl sulfoxide, dichloromethane and ethanol. Insoluble in water.
Merck :13,9137
Stability :Light Sensitive
InChIKey :NKANXQFJJICGDU-QPLCGJKRSA-N
LogP :6.3 at 20℃
CAS DataBase Reference :10540-29-1(CAS DataBase Reference)
IARC :1 (Vol. 66, 100A) 2012
EPA Substance Registry System :Tamoxifen (10540-29-1)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P273 Avoid release to the environment.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

There are two homologous nuclear receptors for the hormone 17β-estradiol (estrogen), commonly called ERα and ERβ. Receptor activation leads to the formation of homo- and hetero-dimers, which in turn interact with accessory proteins to regulate gene transcription. Tamoxifen is a selective estrogen receptor modulator, evoking tissue-dependent effects. It is an antagonist of ER action in breast tissue and breast cancer cells and is reported to be effective in the treatment of early breast cancer to prevent tumor growth. Importantly, tamoxifen has been reported to act as an ER agonist in bone and blood vessels, helping to minimize osteoporosis and reduce the risk of cardiovascular disease in post-menopausal women. Also, tamoxifen is a partial ER agonist in uterine tissues and is reported to increase the risk of endometrial carcinoma.

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