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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Antimetabolites, Antineoplastic >Temozolomide

Temozolomide

Temozolomide Structure
  • ₹8300 - ₹37086.45
  • Product name: Temozolomide
  • CAS: 85622-93-1
  • MF: C6H6N6O2
  • MW: 194.15
  • EINECS:630-358-9
  • MDL Number:MFCD00866492
  • Synonyms:4-methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide;TEMOZOLOMIDE;nsc362856 ;Temozolimide;3,4-Dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, Methazolastone, M&B 39831, Temodal, Temodar,;TEMOZOLOMIDE HCL;Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3,4-dihydro-3-methyl-4-oxo-;3-Methyl-4-oxo-8-imidazolo[5,1-d][1,2,3,5]tetrazinecarboxamide, 8-Carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one, 4-Methyl-5-oxo-2,3,4,6,8-pentazabicyclo[4.3.0]nona-2,7,9-triene-9-carboxamide
8 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 25MG
  • 50MG
  • 100MG
  • 500MG
  • 1G
  • 5G
  • ManufacturerTCI Chemicals (India)
  • Product numberT2744
  • Product descriptionTemozolomide
  • Packaging500MG
  • Price₹8300
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2744
  • Product descriptionTemozolomide
  • Packaging5G
  • Price₹33800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT2577
  • Product descriptionTemozolomide ≥98% (HPLC)
  • Packaging25MG
  • Price₹11539.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number5.00609
  • Product descriptionTemozolomide - CAS 85622-93-1 - Calbiochem
  • Packaging50MG
  • Price₹14100
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1437
  • Product descriptionTemozolomide Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹14884.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number76899
  • Product descriptionTemozolomide VETRANAL?, analytical standard
  • Packaging10MG
  • Price₹19842.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number34219
  • Product descriptionTemozolomide VETRANAL?, analytical standard
  • Packaging25MG
  • Price₹35560.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT2577
  • Product descriptionTemozolomide ≥98% (HPLC)
  • Packaging100MG
  • Price₹37086.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T2744 Temozolomide 500MG ₹8300 2022-05-26 Buy
TCI Chemicals (India) T2744 Temozolomide 5G ₹33800 2022-05-26 Buy
Sigma-Aldrich(India) T2577 Temozolomide ≥98% (HPLC) 25MG ₹11539.45 2022-06-14 Buy
Sigma-Aldrich(India) 5.00609 Temozolomide - CAS 85622-93-1 - Calbiochem 50MG ₹14100 2022-06-14 Buy
Sigma-Aldrich(India) PHR1437 Temozolomide Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹14884.38 2022-06-14 Buy
Sigma-Aldrich(India) 76899 Temozolomide VETRANAL?, analytical standard 10MG ₹19842.23 2022-06-14 Buy
Sigma-Aldrich(India) 34219 Temozolomide VETRANAL?, analytical standard 25MG ₹35560.13 2022-06-14 Buy
Sigma-Aldrich(India) T2577 Temozolomide ≥98% (HPLC) 100MG ₹37086.45 2022-06-14 Buy

Properties

Melting point :212°C dec.
Boiling point :526.6±42.0 °C(Predicted)
Density :1.97±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble10mg/mL, clear
pka :14.77±0.20(Predicted)
form :powder
color :white to light brown
Merck :14,9139
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :BPEGJWRSRHCHSN-UHFFFAOYSA-N
CAS DataBase Reference :85622-93-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H340 May cause genetic defects Germ cell mutagenicity Category 1A, 1B Danger GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Temozolomide (TMZ) is an imidazotetrazine that is converted to a compound capable of alkylating DNA, thus interfering with DNA replication and leading to cytotoxicity in proliferating cells. TMZ is rapidly and completely absorbed from the gastrointestinal tract after oral administration and readily crosses the blood-brain barrier. It is effective in a variety of types of cancer, including aggressive brain cancers.

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