Tenovin-6
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- ₹0
- Product name: Tenovin-6
- CAS: 1011557-82-6
- MF: C25H34N4O2S
- MW: 454.63
- EINECS:200-256-5
- MDL Number:MFCD11976906
- Synonyms:Tenovin-6;4-TERT-BUTYL-N-(4-(5-(DIMETHYLAMINO)PENTANAMIDO)PHENYLCARBAMOTHIOYL)BENZAMIDE HYDROCHLORIDE;N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;Benzamide, N-[[[4-[[5-(dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)-;N-[[[4-[[5-(Dimethylamino)-1-oxopentyl]amino]phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide Tenovin-6;Tenovin-6, >=98%;4-(tert-Butyl)-N-((4-(4-(dimethylamino)butanamido)phenyl)carbAmothioyl)benzamide;Tenovin 6 - Tnv 6
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
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Properties
Density :1.171±0.06 g/cm3(Predicted)
storage temp. :Store at -20° C
solubility :≥22.75 mg/mL in DMSO; insoluble in H2O; ≥2.62 mg/mL in EtOH with ultrasonic
form :solid
pka :9.11±0.70(Predicted)
color :White to off-white
storage temp. :Store at -20° C
solubility :≥22.75 mg/mL in DMSO; insoluble in H2O; ≥2.62 mg/mL in EtOH with ultrasonic
form :solid
pka :9.11±0.70(Predicted)
color :White to off-white
Safety Information
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Description
The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 μM, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 μM, respectively.Related product price
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