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WWL123

WWL123 Structure
  • ₹0
  • Product name: WWL123
  • CAS: 1338575-41-9
  • MF: C28H24N2O3
  • MW: 436.5
  • EINECS:
  • MDL Number:
  • Synonyms:WWL123;QKMMESWNJMOPIF-UHFFFAOYSA-N;Carbamic acid, N-([1,1'-biphenyl]-3-ylmethyl)-N-methyl-, 4'-(aminocarbonyl)[1,1'-biphenyl]-3-yl ester
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :655.2±55.0 °C(Predicted)
Density :1.209±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≤1mg/ml in DMSO
form :crystalline solid
pka :15.90±0.50(Predicted)
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

The serine hydrolase known as α/β-hydrolase domain-containing protein 6 (ABHD6) hydrolyzes 2-arachidonoyl glycerol to regulate its availability at cannabinoid receptors. WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 μM) that demonstrates >10-fold selectivity for ABHD6 compared to a panel of ~35 other serine hydrolases. Inhibition of ABHD6 by WWL123 has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington’s disease as well as in chemically-induced epilepsy models.

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Suppliers and manufacturers

Cayman Chemical Company ApexBio Technology Shanghai Minmin Biotechnology Co., Ltd. Shanghai Weiwei Biological Technology Co., Ltd. Shanghai Hao Biological Technology Co., Ltd. Boao Pike Shanghai Hao Zhun Biological Technology Co., Ltd. Shenzhen Xinbosheng Biological Technology Co., Ltd. Beijing Shengke Boyuan Biotechnology Co., Ltd. Shanghai Haoran Biotechnology Co., Ltd.