XANTHOTOXOL
- ₹0
- Product name: XANTHOTOXOL
- CAS: 2009-24-7
- MF: C11H6O4
- MW: 202.16
- EINECS:217-923-1
- MDL Number:MFCD00017408
- Synonyms:2-g)(1)benzopyran-7-one,9-hydroxy-7h-furo( ;6,7-dihydroxy-5-benzofuranacrylicacigamma-lactone ;8-hydroxypsoralene ;9-hydroxy-7h-furo(3,2-g)(1)benzopyran-7-one ;9-hydroxyfuro[3,2-g]chromen-7-one;9-hydroxy-;Xanthotoxol, froM CnidiuM Monnieri;XANTHOTOXOL
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Properties
Melting point :250°C
Boiling point :428.1±45.0 °C(Predicted)
Density :1.526±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :5.74±0.20(Predicted)
color :Light Beige to Dark Brown
LogP :1.405 (est)
Boiling point :428.1±45.0 °C(Predicted)
Density :1.526±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :5.74±0.20(Predicted)
color :Light Beige to Dark Brown
LogP :1.405 (est)
Safety Information
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Description
Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s = 23.59 and 15.57 μM, respectively). Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita (IC50 = 68 mg/L). In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively. It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.More related product prices
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Suppliers and manufacturers
A.J Chemicals
CLEARSYNTH LABS LTD.
Chengdu Greenpure Biopharma CO.,Ltd
Chengdu GLP biotechnology Co Ltd
Chengdu Biopurify Phytochemicals Ltd.
Shaanxi Pioneer Biotech Co., Ltd .
Chongqing Chemdad Co., Ltd
Neostar United (Changzhou) Industrial Co., Ltd.
Jiangxi Lotchem Co.,Ltd.