Zoledronic acid hydrate
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- ₹7400 - ₹45681.5
- Product name: Zoledronic acid hydrate
- CAS: 165800-06-6
- MF: C5H12N2O8P2
- MW: 290.1
- EINECS:
- MDL Number:MFCD08448695
- Synonyms:[1-HYDROXY-(1H-IMIDAZOL-1-YL)-PHOSPHONOETHYL] PHOSPHONIC ACID MONOHYDRATE;(1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid hydrate;(1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid monohydrate;PHOSPHONIC ACID, [1-HYDROXY-2-(1H-IMIDAZOL-1-YL)ETHYLIDENE]BIS-, MONOHYDRATE;zoledronic acid hydrate;ZoledronicacidforInjection;[1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate;P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate
5 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 10MG
- 50MG
- 1G
- 5G
- ManufacturerTCI Chemicals (India)
- Product numberZ0031
- Product descriptionZoledronic Acid Monohydrate
- Packaging1G
- Price₹7400
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberZ0031
- Product descriptionZoledronic Acid Monohydrate
- Packaging5G
- Price₹21500
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0223
- Product descriptionZoledronic acid monohydrate ≥98% (HPLC)
- Packaging10MG
- Price₹11268.83
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPHR1893
- Product descriptionZoledronic Acid Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging1G
- Price₹22743.33
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0223
- Product descriptionZoledronic acid monohydrate ≥98% (HPLC)
- Packaging50MG
- Price₹45681.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | Z0031 | Zoledronic Acid Monohydrate | 1G | ₹7400 | 2022-05-26 | Buy |
| TCI Chemicals (India) | Z0031 | Zoledronic Acid Monohydrate | 5G | ₹21500 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | SML0223 | Zoledronic acid monohydrate ≥98% (HPLC) | 10MG | ₹11268.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1893 | Zoledronic Acid Pharmaceutical Secondary Standard; Certified Reference Material | 1G | ₹22743.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0223 | Zoledronic acid monohydrate ≥98% (HPLC) | 50MG | ₹45681.5 | 2022-06-14 | Buy |
Properties
Melting point :245 °C(dec.)
storage temp. :2-8°C
solubility :H2O: ≥2mg/mL
form :powder
color :white to beige
Merck :14,10187
InChIKey :FUXFIVRTGHOMSO-UHFFFAOYSA-N
CAS DataBase Reference :165800-06-6(CAS DataBase Reference)
storage temp. :2-8°C
solubility :H2O: ≥2mg/mL
form :powder
color :white to beige
Merck :14,10187
InChIKey :FUXFIVRTGHOMSO-UHFFFAOYSA-N
CAS DataBase Reference :165800-06-6(CAS DataBase Reference)
Safety Information
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Description
Zoledronic acid is a third-generation heterocyclic nitrogen-containing bisphosphonate that inhibits the prenylation of GTPases critical to the signaling events related to osteoclast-mediated bone resorption. It has a high affinity for hydroxyapatite (Ki = 3.47 μM) and binds directly to mineralized bone where it decreases bone resorption by inhibiting osteoclast proliferation and inducing osteoclast apoptosis. At μM concentrations, zoledronic acid demonstrates antitumor effects in vitro against breast, prostate, and myeloma cancer cells by inducing cytostasis and prevents bone metastases through its inhibitory effects on adhesion molecules, tumor cell invasion, and angiogenesis. Zoledronic acid has been used in the treatment of osteoporosis, Paget’s disease, metastatic bone disease, multiple myeloma, hypercalcemia of malignancy, and skeletal-related events associated with metastatic castrate-resistant prostate cancer.More related product prices
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