AZ 628
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- ₹11799.3 - ₹47552.4
- Product name: AZ 628
- CAS: 878739-06-1
- MF: C27H25N5O2
- MW: 451.52
- EINECS:
- MDL Number:MFCD17392577
- Synonyms:3-(1-Cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]benzamide;AZ-628;AZ628/AZ-628;AZD628;3-(2-cyanopropan-2-yl)-N-(4-methyl-3-(3-methyl-4-oxo-3,4-dihydroquinazolin-6-ylamino)phenyl)benzamide;AZ628, >=99%;3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)ben;Benzamide, 3-(1-cyano-1-methylethyl)-N-[3-[(3,4-dihydro-3-methyl-4-oxo-6-quinazolinyl)amino]-4-methylphenyl]-
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0785
- Product descriptionAZ628 ≥98% (HPLC)
- Packaging5MG
- Price₹11799.3
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0785
- Product descriptionAZ628 ≥98% (HPLC)
- Packaging25MG
- Price₹47552.4
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0785 | AZ628 ≥98% (HPLC) | 5MG | ₹11799.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0785 | AZ628 ≥98% (HPLC) | 25MG | ₹47552.4 | 2022-06-14 | Buy |
Properties
Density :1.21±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL, clear
form :powder
pka :12.92±0.70(Predicted)
color :white to beige
Safety Information
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Description
The Raf kinases activate cellular pathways that lead to cell proliferation and can contribute to certain types of cancer. Mutations in the kinase B-Raf are involved in a wide range of cancers. In particular, the mutation B-RafV600E occurs in melanomas and other types of cancer but is poorly targeted by many inhibitors of wild type B-Raf. AZ 628 is a quinazilinone that inhibits several Raf kinases, including B-Raf, B-RafV600E, and c-Raf-1 (IC50s = 105, 34, and 29 nM in in vitro kinase assays). It also prevents activation of several tyrosine kinases, including VEGFR2, DDR2, Lyn, Flt1, and FMS. In colon and melanoma cell lines carrying B-RafV600E mutations, AZ 628 is reported to inhibit anchorage-dependent and -independent growth, induce cell cycle arrest, and cause apoptosis.Related product price
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