BAFILOMYCIN B1
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- ₹17785.48
- Product name: BAFILOMYCIN B1
- CAS: 88899-56-3
- MF: C44H65NO13
- MW: 815.99
- EINECS:
- MDL Number:MFCD33021141
- Synonyms:BAFILOMYCIN B1;BAFILOMYCIN B1 MONOHYDRATE FROM STREPTO- MYCES SPECIES;BafilomycinB1fromStreptomycesgriseus;bafilomycin b1from streptomyces sp.;hygrolidin,37-decarboxy-2-demethyl-37-(((2-hydroxy-5-oxo-1-cyclopenten-1-yl)am ;ino)carbonyl)-2-methoxy-24-methyl- ;37-De(carboxy)-2-demethyl-37-[[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]carbonyl]-2-methoxy-24-methylhygrolidin;2-Butenoic acid, 4-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-4-oxo-, (2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14Z)-10-hydroxy-3,15-dimethoxy-7,9,11,13-tetramethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethy...
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Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product number11707
- Product descriptionBafilomycin B1 from Streptomyces sp. ≥80% (HPLC)
- Packaging1MG
- Price₹17785.48
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 11707 | Bafilomycin B1 from Streptomyces sp. ≥80% (HPLC) | 1MG | ₹17785.48 | 2022-06-14 | Buy |
Properties
storage temp. :−20°C
solubility :DMSO: Soluble; Methanol: Unstable
form :powder or crystals
color :faint yellow to yellow
BRN :4640118
Stability :Hygroscopic
solubility :DMSO: Soluble; Methanol: Unstable
form :powder or crystals
color :faint yellow to yellow
BRN :4640118
Stability :Hygroscopic
Safety Information
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| Signal word: | Danger | ||||||||||
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Description
The bafilomycins are fungal plecomacrolide antibiotics with a 16-membered lactone ring. They inhibit the growth of Gram-positive bacteria and fungi. Bafilomycin B1 is a selective, reversible inhibitor of vacuolar H+-ATPases (V-ATPases), blocking these proton pumps in mammalian, plant, or fungal cells with an IC50 value in the 4-400 nM range. It is at least 1,000-fold less potent at most other types of ATPases. When used at 100 nM, the related macrolide bafilomycin A1 blocks V-ATPase-mediated acidification of lysosomes during autophagy, preventing protein degradation. Remarkably, at only 1 nM, both bafilomycin A1 or B1 dramatically attenuate chloroquine-induced apoptosis of neurons without altering autophagy.More related product prices
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