BQ-788
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- ₹20567.5
- Product name: BQ-788
- CAS: 156161-89-6
- MF: C34H52N5NaO7
- MW: 665.81
- EINECS:
- MDL Number:MFCD00797882
- Synonyms:BQ-788 SODIUM;BQ-788 SYNTHETIC >97% ETB ENDOTHELIN REC EPT;N-[(cis-2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl-1-(methoxycarbonyl)-D-tryptophyl-D-norleucinesodiumsalt;1-ELAIDYLPHOSPHOCHOLINE, >97%;N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-4-methyl-L-leucyl]-1-(methoxycarbonyl)-D-tryptophyl]-D-norleucine sodium salt, 2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle;N-[N-[N-[(2,6-Dimethyl-1-piperidinyl)carbonyl]-;DMpc-gaMMa-MeLeu-D-Trp(1-CO2CH3)-D-Nle.Na (DMpc : cis-2,6-DiMethylpiperidinocarbonyl);2,6-Dimethylpiperidinecarbonyl-γ-Methyl-Leu-Nin-(Methoxycarbonyl)-D-Trp-D-Nle
1 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 200μG
- ManufacturerSigma-Aldrich(India)
- Product numberB157
- Product descriptionBQ-788 ≥95%, solid
- Packaging200μG
- Price₹20567.5
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | B157 | BQ-788 ≥95%, solid | 200μG | ₹20567.5 | 2022-06-14 | Buy |
Properties
storage temp. :-20°C
solubility :acetonitrile: 0.3 mg/mL
form :solid
color :white
solubility :acetonitrile: 0.3 mg/mL
form :solid
color :white
Safety Information
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Description
The endothelin (ET) family of proteins mediate a variety of responses, with ET-1 being a potent and long-lasting constrictor of human cardiovascular vessels. These proteins activate the G protein-coupled receptors ETA and ETB, with ETB being non-specific for ET protein form. BQ-788 is a potent, selective antagonist of ETB (IC50 = 1.2 nM for blocking ET-1 binding to human Girardi heart cells). It weakly inhibits the binding of ET-1 to ETA receptors on human neuroblastoma SK-N-MC cells (IC50 = 1300 nM). BQ-788 competitively antagonizes the vasoconstriction induced by an ETB-selective agonist on isolated rabbit pulmonary arteries, blocks ET-1 induced bronchoconstriction in guinea pigs, and abolishes an ET-1 mediated depressor response in rats.Suppliers and manufacturers
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