Bufalin
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- ₹23839.99 - ₹53756.95
- Product name: Bufalin
- CAS: 465-21-4
- MF: C24H34O4
- MW: 386.53
- EINECS:
- MDL Number:MFCD30207876
- Synonyms:22-dienolide,3,14-dihydroxy-,(3-beta,5-beta)-bufa-2 ;Bufalin, >=98%;22-dienolide,3-beta,14-dihydroxy-5-beta-bufa-2 ;BUFA-20,22-DIENOLIDE, 3,14-DIHYDROXY-, (3B,5B)-;(3BETA,5BETA)-3,14-DIHYDROXYBUFA-20,22-DIENOLIDE;3-BETA-14-DIHYDROXY-5-BETA-BUFA-20,22-DIENOLIDE;3BETA,14-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE;5BETA,20[22]-BUFADIENOLIDE-3BETA,14-DIOL
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number203900
- Product descriptionBufalin - CAS 465-21-4 - Calbiochem A cardiotonic steroid isolated from toads of Bufo species that potently inhibits ouabain-sensitive Na+,K+-ATPase activity (IC?? = 1.4 nM).
- Packaging10MG
- Price₹23839.99
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberB0261
- Product descriptionBufalin
- Packaging10MG
- Price₹53756.95
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 203900 | Bufalin - CAS 465-21-4 - Calbiochem A cardiotonic steroid isolated from toads of Bufo species that potently inhibits ouabain-sensitive Na+,K+-ATPase activity (IC?? = 1.4 nM). | 10MG | ₹23839.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B0261 | Bufalin | 10MG | ₹53756.95 | 2022-06-14 | Buy |
Properties
Melting point :242-243°
alpha :D -20°
Boiling point :556.6±50.0 °C(Predicted)
Density :1.226±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:36.0(Max Conc. mg/mL);93.14(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);64.68(Max Conc. mM)
Ethanol:27.5(Max Conc. mg/mL);71.15(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.78(Max Conc. mM) pka :15.01±0.70(Predicted)
form :White to off-white solid
color :White to off-white
InChIKey :QEEBRPGZBVVINN-ONGIWDLKSA-N
alpha :D -20°
Boiling point :556.6±50.0 °C(Predicted)
Density :1.226±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO:36.0(Max Conc. mg/mL);93.14(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);64.68(Max Conc. mM)
Ethanol:27.5(Max Conc. mg/mL);71.15(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.78(Max Conc. mM) pka :15.01±0.70(Predicted)
form :White to off-white solid
color :White to off-white
InChIKey :QEEBRPGZBVVINN-ONGIWDLKSA-N
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Bufalin is a cardiotonic steroid first isolated from toad venom and used in traditional Asian medicine. It inhibits the Na+/K+-ATPase transporter (Kds = 42, 45, and 40 nM for the α1, α2, and α3 subunits, respectively). Intravenously administered bufalin is cleared rapidly, with a plasma half-life of 25 minutes in dogs and rats. Bufalin inhibits steroid receptor coactivator 1 (SRC-1) and SRC-3 at doses as low as 5 nM, promotes the degradation of SRC-3 protein, and inhibits cancer cell growth both in vitro and in vivo. It can also impact the action and expression of several other proteins and kinases as well as induce apoptosis in various cancer cells.Related product price
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