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ChemicalBook > Product Catalogue >Natural Products >Terpenes >Costunolide

Costunolide

Costunolide Structure
  • ₹9000 - ₹43830.43
  • Product name: Costunolide
  • CAS: 553-21-9
  • MF: C15H20O2
  • MW: 232.32
  • EINECS:
  • MDL Number:MFCD00210262
  • Synonyms:(3AS,6E,10E,11AR)-3A,4,5,8,9,11A-HEXAHYDRO-6,10-DIMETHYL-3-METHYLENE-CYCLODECA[B]FURAN-2(3H)-ONE;COSTUNOLIDE;(e,e)-6-alpha-hydroxygermacra-1(10),4,11(13)-trien-12-oicacidgamma-lactone ;germacra-1(10),4,11(13)-trien-12-oicacid,6-alpha-hydroxy-,gamma-lactone,(e, ;Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3- methylene-, [3aS-(3aR*,6E,10E,11aS*)]-;CUSTUNOLIDE;Cyclodeca[b]furan-2(3H)-one,3a,4,5,8,9,11a-;hexahydro-6,10-dimethyl-3-methylene-,(3aS,6E,10E,11aR)-
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberC2921
  • Product descriptionCostunolide
  • Packaging25MG
  • Price₹9000
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC2921
  • Product descriptionCostunolide
  • Packaging100MG
  • Price₹15700
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0417
  • Product descriptionCostunolide ≥97% (HPLC)
  • Packaging5MG
  • Price₹10727.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0417
  • Product descriptionCostunolide ≥97% (HPLC)
  • Packaging25MG
  • Price₹43830.43
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C2921 Costunolide 25MG ₹9000 2022-05-26 Buy
TCI Chemicals (India) C2921 Costunolide 100MG ₹15700 2022-05-26 Buy
Sigma-Aldrich(India) SML0417 Costunolide ≥97% (HPLC) 5MG ₹10727.58 2022-06-14 Buy
Sigma-Aldrich(India) SML0417 Costunolide ≥97% (HPLC) 25MG ₹43830.43 2022-06-14 Buy

Properties

Melting point :106-107 °C
Boiling point :385.4±42.0 °C(Predicted)
Density :1.03±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL (clear solution)
form :powder
color :white to beige
InChIKey :HRYLQFBHBWLLLL-GRFSRWIASA-N
LogP :4.049 (est)
CAS DataBase Reference :553-21-9(CAS DataBase Reference)
NIST Chemistry Reference :Germacra-1(10),4,11(13)-trien-12-oic acid, 6«alpha»-hydroxy-, «gamma»-lactone, (e,e)-(553-21-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.

Description

Costunolide is a sesquiterpene lactone that is found naturally in certain plant extracts and in alternative medicine oils. It reduces growth (EC50 = 3-35 μM) and induces apoptosis in assorted cancer cell lines. Costunolide inhibits the activation of Akt (15 μM) in endometriotic epithelial cells and STAT3 activation in THP-1 cells (EC50 = 10 μM). It also inhibits telomerase activity in NALM-6 cells.

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