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CARIPORIDE

CARIPORIDE Structure
  • ₹8530.1 - ₹34445.15
  • Product name: CARIPORIDE
  • CAS: 159138-80-4
  • MF: C12H17N3O3S
  • MW: 283.35
  • EINECS:1592732-453-0
  • MDL Number:MFCD00864683
  • Synonyms:CARIPORIDE;N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide;N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide;N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide;BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-;Cariporide (HOE-642);CS-1692;Sodium/hydrogen Exchanger,Na+/H+ Exchanger (NHE),inhibit,Sodium-hydrogen Exchanger,HOE642,Inhibitor,Cariporide,HOE 642
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1360
  • Product descriptionCariporide ≥98% (HPLC)
  • Packaging5MG
  • Price₹8530.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1360
  • Product descriptionCariporide ≥98% (HPLC)
  • Packaging25MG
  • Price₹34445.15
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1360 Cariporide ≥98% (HPLC) 5MG ₹8530.1 2022-06-14 Buy
Sigma-Aldrich(India) SML1360 Cariporide ≥98% (HPLC) 25MG ₹34445.15 2022-06-14 Buy

Properties

Melting point :90-94° (dec)
Density :1.34
storage temp. :2-8°C
solubility :insoluble in H2O; ≥12.05 mg/mL in DMSO; ≥2.675 mg/mL in EtOH with gentle warming and ultrasonic
form :powder
color :white to beige

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The sodium-hydrogen exchanger isoform-1 (NHE-1) is the predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis. It plays an important role in the myocardial response to ischemia-reperfusion. Cariporide is a benzoylguanidine compound that inhibits NHE-1 with IC50 values ranging from 0.03-3.4 μM. It displays selectivity for NHE-1 over NHE-2, NHE-3, and NHE-5 (IC50s = 4.3-62, 1->100, and >30 μM, respectively). The cardioprotective efficacy of cariporide has been examined in clinical investigations of patients at risk for myocardial infarction.

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