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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Pharmaceutical Impurity Reference Standards >Cilastatin sodium

Cilastatin sodium

Cilastatin sodium Structure
  • ₹5200 - ₹31186.83
  • Product name: Cilastatin sodium
  • CAS: 81129-83-1
  • MF: C16H25N2O5S.Na
  • MW: 380.44
  • EINECS:279-694-4
  • MDL Number:MFCD08459332
  • Synonyms:Cilastatine;Cilastatin sodium;Sodium 7-(2-amino-2-carboxy-ethyl)sulfanyl-2-(2,2-dimethylcyclopropyl)carbonylamino-hept-2-enoate;Sodium hydrogen 7-[(2-amino-2-carboxylatoethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]hept-2-enoate;Sodium Cilastatin;[R-[R*,S*-(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid monosodium salt;(Z)-7-[(R)-2-Amino-2-carboxyethylthio]-2-[(S)-2,2-dimethylcyclopropylcarbonylamino]-2-heptenoic acid 1-sodium salt;(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoicacidsodiumsalt
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)
  • TCI Chemicals (India)

Package

  • 50MG
  • 100MG
  • 2ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1283
  • Product descriptionCilastatin sodium Ready Made Solution 50?mg/mL in DMSO/H2O, 1:1
  • Packaging2ML
  • Price₹17236.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5743
  • Product descriptionCilastatin sodium salt ≥98% (HPLC)
  • Packaging100MG
  • Price₹31186.83
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberC3547
  • Product descriptionCilastatin Sodium Salt
  • Packaging50MG
  • Price₹5200
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML1283 Cilastatin sodium Ready Made Solution 50?mg/mL in DMSO/H2O, 1:1 2ML ₹17236.8 2022-06-14 Buy
Sigma-Aldrich(India) C5743 Cilastatin sodium salt ≥98% (HPLC) 100MG ₹31186.83 2022-06-14 Buy
TCI Chemicals (India) C3547 Cilastatin Sodium Salt 50MG ₹5200 2022-05-26 Buy

Properties

Melting point :>160°C (dec.)
Flash point :87℃
storage temp. :2-8°C
solubility :Very soluble in water and in methanol, slightly soluble in anhydrous ethanol, very slightly soluble in dimethyl sulfoxide, practically insoluble in acetone and in methylene chloride.
form :Solid
pka :pKa1 2.0; pKa2 4.4; pKa3 9.2(at 25℃)
color :White
biological source :synthetic (organic)
Water Solubility :water: 10mg/mL, clear, colorless to faintly yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
CAS DataBase Reference :81129-83-1(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cilastatin Na (81129-83-1) is a dehydropeptidase-1 inhibitor. Inhibits the proteolytic conversion of leukotriene D4?to E4.1? Inhibits the mammalian β-lactamase renal dipeptidase (dehydropeptidase-1, DPEP1) and thus is used as an antibacterial adjunct to extend the half-life of β-lactam antibiotics.2?Cilastatin also inhibits bacterial metallo-β-lactamase and thereby may block resistance to the carbapenem family of antibiotics in certain bacteria.3? Suppresses invasion and metastasis of DPEP1-expressing tumor cells.4

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