Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >API >Circulatory system drugs >Lipid regulating drugs >Sitagliptin

Sitagliptin

Sitagliptin Structure
  • ₹0
  • Product name: Sitagliptin
  • CAS: 486460-32-6
  • MF: C16H15F6N5O
  • MW: 407.31
  • EINECS:690-730-1
  • MDL Number:MFCD09838015
  • Synonyms:Sitagliptin;(3R)-3-AMino-1-[3-(trifluoroMethyl)-5,6,7,8-tetrahydro-1,2,4-riazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-rifluorophenyl) butan-1-one;Sitagliptin-D4 HCL;Hsdb 7516;C53323300;Metformin / sitagliptin;Metformin hydrochloride mixture with sitagliptin phosphate;Metformin mixture with sitagliptin
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :114.1-115.7 °C
Boiling point :529.9±60.0 °C(Predicted)
Density :1.61±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : ≥ 50 mg/mL (122.76 mM)
form :Solid
pka :7.20±0.10(Predicted)
color :White to off-white
InChI :InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1
InChIKey :MFFMDFFZMYYVKS-SECBINFHSA-N
SMILES :C(N1CCN2C(C(F)(F)F)=NN=C2C1)(=O)C[C@H](N)CC1=CC(F)=C(F)C=C1F
CAS DataBase Reference :486460-32-6(CAS DataBase Reference)
EPA Substance Registry System :1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- (486460-32-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic αcells, which leads to reduced hepatic glucose production.

More related product prices

5-Aza-2'-deoxycytidine Sitagliptin phosphate monohydrate 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Doxazosin mesylate Tris Base 3-Aminophenol 6-Aminocaproic acid Sitafloxacin 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-[(tetrahydro-2-furanyl)carbonyl]piperazine hydrochloride Alfuzosin hydrochloride Glycine Cilastatin Terazosin Pravastatin Cimetidine Cilastatin sodium

Related product price

Suppliers and manufacturers

Jigs Chemical ltd Cadila Pharmaceuticals Ltd HEMA PHARMACEUTICALS PVT LTD SGMR PHARMACEUTICALS PVT LTD Bulat Pharmaceutical Pvt Ltd Bhausa Life Sciences Lofty labs Lupin Ltd Glenmark Pharmaceuticals Limited FDC Limited