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ChemicalBook > Product Catalogue >API >Digestive system drugs >Other digestive system drugs >Cimetidine

Cimetidine

Cimetidine Structure
  • ₹8356.9 - ₹27603.75
  • Product name: Cimetidine
  • CAS: 51481-61-9
  • MF: C10H16N6S
  • MW: 252.34
  • EINECS:257-232-2
  • MDL Number:MFCD00133296
  • Synonyms:SKF-92334;N-CYANO-N'-METHYL-N''-[[2-[(5-METHYL-1H-IMIDAZOL-4-YL)METHYL]THIO]ETHYL]GUANIDINE;Cimetidine (base and/or unspecified salts);Peptol;Tametin;Tratul;Ulcedin;Ulcedine
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 1G
  • 5G
  • 10G
  • 25G
  • ManufacturerTCI Chemicals (India)
  • Product numberC1252
  • Product descriptionCimetidine
  • Packaging25G
  • Price₹12900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR1075
  • Product descriptionCimetidine Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging1G
  • Price₹8356.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4522
  • Product descriptionCimetidine
  • Packaging5G
  • Price₹8573.4
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4522
  • Product descriptionCimetidine
  • Packaging10G
  • Price₹14083.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC4522
  • Product descriptionCimetidine
  • Packaging25G
  • Price₹27603.75
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) C1252 Cimetidine 25G ₹12900 2022-05-26 Buy
Sigma-Aldrich(India) PHR1075 Cimetidine Pharmaceutical Secondary Standard; Certified Reference Material 1G ₹8356.9 2022-06-14 Buy
Sigma-Aldrich(India) C4522 Cimetidine 5G ₹8573.4 2022-06-14 Buy
Sigma-Aldrich(India) C4522 Cimetidine 10G ₹14083.33 2022-06-14 Buy
Sigma-Aldrich(India) C4522 Cimetidine 25G ₹27603.75 2022-06-14 Buy

Properties

Melting point :139-144°C
Boiling point :476.2±55.0 °C(Predicted)
Density :1.2583 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :2-8°C
solubility :Slightly soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute mineral acids.
form :Solid
pka :pKa 6.80 (Uncertain)
color :White to Off-White
Water Solubility :0.5 g/100 mL at 20 ºC
Merck :14,2279
InChIKey :AQIXAKUUQRKLND-UHFFFAOYSA-N
CAS DataBase Reference :51481-61-9(CAS DataBase Reference)
NIST Chemistry Reference :Cimetidine(51481-61-9)
IARC :3 (Vol. 50) 1990
EPA Substance Registry System :Guanidine, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- (51481-61-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H303 May be harmfulif swallowed Acute toxicity,oral Category 5 P312
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P405 Store locked up.

Description

Cimetidine (brand name: Tagamet) is a kind of histamine H2 receptor antagonist being capable of inhibiting the production of stomach acid, which reduces the gastric volume and acidity. It is mainly used for the treatment of heartburn and peptic ulcers. There are also evidences that it can be used for the treatment of common warts, chronic calcific tendinitis of the shoulder, and even colorectal cancer. It is capable of not only inhibiting the gastric acid secretion, as well as pepsin and gastrins output, but also inhibiting the activity of cytochrome P450. It reduces the gastric acid secretion through binding to the H2 receptor locating on the basolateral membrane of the gastric parietal cell, and further blocking histamine effect.

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