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ChemicalBook > Product Catalogue >Biochemical Engineering >Amino Acids and Derivatives >Proline derivatives >cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline

cis-4-Hydroxy-L-proline Structure
  • ₹5700 - ₹57675.6
  • Product name: cis-4-Hydroxy-L-proline
  • CAS: 618-27-9
  • MF: C5H9NO3
  • MW: 131.13
  • EINECS:210-542-1
  • MDL Number:MFCD00064319
  • Synonyms:(S)-Allo-hydroxyproline;cis-4-Hydroxy-L-proline collagen synthesis inhibitor;L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLIC ACID;L-ALLO-4-HYDROXY-2-PYRROLIDINECARBOXYLLIC ACID;L-ALLO-HYDROXYPROLINE;CIS-4-HYDROXY-L-PROLINE;CIS-L-4-HYDROXYPROLINE;CIS-HYDROXYPROLINE
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 50MG
  • 100MG
  • 250MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberH1169
  • Product descriptioncis-4-Hydroxy-L-proline
  • Packaging100MG
  • Price₹5700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberH1169
  • Product descriptioncis-4-Hydroxy-L-proline
  • Packaging1G
  • Price₹6900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH1637
  • Product descriptioncis-4-Hydroxy-L-proline collagen synthesis inhibitor
  • Packaging50MG
  • Price₹6397.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH1637
  • Product descriptioncis-4-Hydroxy-L-proline collagen synthesis inhibitor
  • Packaging250MG
  • Price₹17384.95
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberH1637
  • Product descriptioncis-4-Hydroxy-L-proline collagen synthesis inhibitor
  • Packaging1G
  • Price₹57675.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) H1169 cis-4-Hydroxy-L-proline 100MG ₹5700 2022-05-26 Buy
TCI Chemicals (India) H1169 cis-4-Hydroxy-L-proline 1G ₹6900 2022-05-26 Buy
Sigma-Aldrich(India) H1637 cis-4-Hydroxy-L-proline collagen synthesis inhibitor 50MG ₹6397.58 2022-06-14 Buy
Sigma-Aldrich(India) H1637 cis-4-Hydroxy-L-proline collagen synthesis inhibitor 250MG ₹17384.95 2022-06-14 Buy
Sigma-Aldrich(India) H1637 cis-4-Hydroxy-L-proline collagen synthesis inhibitor 1G ₹57675.6 2022-06-14 Buy

Properties

Melting point :257 °C (dec.) (lit.)
alpha :-59 º (c=2, H2O)
Boiling point :242.42°C (rough estimate)
Density :1.3121 (rough estimate)
refractive index :-59 ° (C=2, H2O)
storage temp. :Keep in dark place,Sealed in dry,Room Temperature
solubility :soluble
form :Powder
pka :2.14±0.40(Predicted)
color :White to beige
Water Solubility :soluble
Merck :14,4840
BRN :81440
InChIKey :PMMYEEVYMWASQN-IMJSIDKUSA-N
CAS DataBase Reference :618-27-9(CAS DataBase Reference)
EPA Substance Registry System :L-Proline, 4-hydroxy-, (4S)- (618-27-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

cis-4-Hydroxy-L-proline (CHP) is a proline analog that inhibits collagen synthesis and has been used as an anticancer compound. CHP blocked myotube formation and expression of sarcomeric myosin heavy chain in C2C12 murine skeletal muscle cells. CHP inhibited proliferation of murine Panc02 pancreatic carcinoma cell line3 and rat pancreatic carcinoma cell line DSL6A. cis-4-Hydroxy-L-proline and other hydrosyl-L-prolines are important intermediates for chiral synthesis of potential drugs.

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Suppliers and manufacturers

Suven Pharmaceuticals Limited ARRKEM LIFE SCIENCES PRIVATE LIMITED Tulasi Labs Clearsynth Labs Maas Pharma Chemicals CHEMSWORTH A.J Chemicals CLEARSYNTH LABS LTD. TCI Chemicals (India) Pvt. Ltd.
Capot Chemical Co.,Ltd.