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ChemicalBook > Product Catalogue >Analytical Chemistry >Standard >Forensic and veterinary standards >(-)-COTININE

(-)-COTININE

(-)-COTININE Structure
  • ₹2673.3 - ₹45529.95
  • Product name: (-)-COTININE
  • CAS: 486-56-6
  • MF: C10H12N2O
  • MW: 176.22
  • EINECS:207-634-9
  • MDL Number:MFCD00077696
  • Synonyms:L-COTININE;(-)-COTININE;(S)-(-)-1-METHYL-5-(3-PYRIDIYL)-2-PYRROLIDINONE;[S]-1-METHYL-5-[3-PYRIDYL]-2-PYRROLIDINONE;S(-)-1-METHYL-5-(3-PYRIDYL)-2-PYRROLIDONE;(s)-1-methyl-5-(3-pyridinyl)-2-pyrrolidinone ;(s)-2-pyrrolidinon ;1-Methyl-5-(3-pyridinyl)-2-pyrrolidinone
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Brand

  • Sigma-Aldrich(India)

Package

  • 25MG
  • 50MG
  • 250MG
  • 1ML
  • 1G
  • ManufacturerSigma-Aldrich(India)
  • Product numberC-016
  • Product description(−)-Cotinine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
  • Packaging1ML
  • Price₹2673.3
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product number74003
  • Product description(−)-Cotinine analytical standard
  • Packaging25MG
  • Price₹6679.03
  • Updated2022-06-14
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  • ManufacturerSigma-Aldrich(India)
  • Product numberC5923
  • Product description(−)-Cotinine ≥98%
  • Packaging250MG
  • Price₹13206.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberC5923
  • Product description(−)-Cotinine ≥98%
  • Packaging1G
  • Price₹26034.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2533
  • Product descriptionNicotine Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging50MG
  • Price₹45529.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) C-016 (−)-Cotinine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 1ML ₹2673.3 2022-06-14 Buy
Sigma-Aldrich(India) 74003 (−)-Cotinine analytical standard 25MG ₹6679.03 2022-06-14 Buy
Sigma-Aldrich(India) C5923 (−)-Cotinine ≥98% 250MG ₹13206.5 2022-06-14 Buy
Sigma-Aldrich(India) C5923 (−)-Cotinine ≥98% 1G ₹26034.13 2022-06-14 Buy
Sigma-Aldrich(India) PHR2533 Nicotine Related Compound C Pharmaceutical Secondary Standard; Certified Reference Material 50MG ₹45529.95 2022-06-14 Buy

Properties

Melting point :40-42 °C(lit.)
Boiling point :250 °C150 mm Hg(lit.)
alpha :[α]D20 -18~-22° (c=1, C2H5OH)
Density :1.1102 (rough estimate)
refractive index :1.7110 (estimate)
Flash point :>230 °F
storage temp. :Sealed in dry,2-8°C
solubility :Chloroform (Sparingly), DMSO (Slightly), Methanol (Sparingly)
form :Solid
pka :4.72±0.12(Predicted)
color :Colourless to Very Dark Orange Oil
optical activity :[α]/D -21±2°, c = 1 in ethanol
Water Solubility :Not miscible or difficult to mix in water. Soluble in dimethyl sulfoxide (100 mM), ethanol (50 mg/ml, yielding a clear, faint yellow to yellow solution), methanol and chloroform.
Merck :14,2553
BRN :83099
Stability :Stable. Incompatible with strong oxidizing agents. May be heat sensitive - store cold.
EPA Substance Registry System :Cotinine (486-56-6)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Cotinine is a minor alkaloid found in tobacco plants and is a major metabolite of nicotine. It has a long pharmacological half-life (15-19 hours) compared to that of nicotine (2-3 hours) and is often used as a biomarker to detect tobacco use. Cotinine binds nicotinic- and muscarinic-type acetylcholine receptors with minimal receptor desensitization and demonstrates antipsychotic drug-like properties in behavioral models, neuroprotective properties in neurodegenerative disease models, and enhances attention in a delayed matching-to-sample task.

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