Crisaborole

₹10619.33 - ₹42877.83
Product name: Crisaborole
CAS: 906673-24-3
MF: C14H10BNO3
MW: 251.05
EINECS:250-635-4
MDL Number:MFCD17169940
Synonyms:AN-2728, >=98%;AN2728, Crisaborole;Crisaborole (AN2728);AN 2728;AN2728/AN-2728;4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzonitrile;4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile;AN-2728;AN2728;AN 2728

Price2 Properties Safety Information Description

2 prices

Selected condition：

Brand

Sigma-Aldrich(India)

Package

5MG
25MG

ManufacturerSigma-Aldrich(India)
Product numberPZ0037
Product descriptionCrisaborole ≥98% (HPLC)
Packaging5MG
Price₹10619.33
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberPZ0037
Product descriptionCrisaborole ≥98% (HPLC)
Packaging25MG
Price₹42877.83
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	PZ0037	Crisaborole ≥98% (HPLC)	5MG	₹10619.33	2022-06-14	Buy
Sigma-Aldrich(India)	PZ0037	Crisaborole ≥98% (HPLC)	25MG	₹42877.83	2022-06-14	Buy

Properties

Melting point :>130°C (softened)
Boiling point :425.9±55.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO (Slightly), Methanol (Slightly)
pka :7.00±0.20(Predicted)
form :powder
color :white to beige
Stability :Hygroscopic
InChI :InChI=1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChIKey :USZAGAREISWJDP-UHFFFAOYSA-N
SMILES :C(#N)C1=CC=C(OC2=CC=C3B(O)OCC3=C2)C=C1

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P311	Call a POISON CENTER or doctor/physician.

Description

Crisaborole is a phosphodiesterase- 4 (PDE4) inhibitor that was approved by FDA on December 14, 2016 as Eucrisa, a topical treatment of for mild to moderate atopic dermatitis (AD) in patients aged two years and older. The drug, which was developed by Anacor Pharmaceuticals and later acquired and marketed by Pfizer, is delivered as a 2% ointment, which is applied topically. Its structure contains a boron atom, which facilitates skin penetration and binding to the bimetal center of the phosphodiesterase 4 enzyme. The unique employment of boron within the chemical structure of the drug is designed to enable selective engagement of PDE4 (an enzyme involved in the conversion of cAMP into AMP, which signals for downstream inflammatory events), effective penetration of the drug through human skin, and rapid clearance to limit systemic circulation.

Suppliers and manufacturers

Halcyon Labs Pvt. Ltd Viruj Pharmaceuticals Pvt Ltd Metrochem API Private Limited Honour Lab Limited Virupaksha Organics Pvt Ltd Biophore India Pharmaceuticals Pvt Ltd A.J Chemicals CHEMSWORTH CLEARSYNTH LABS LTD. Pharmaffiliates Analytics and Synthetics P. Ltd

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