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dihydrolycorine

dihydrolycorine Structure
  • ₹0
  • Product name: dihydrolycorine
  • CAS: 6271-21-2
  • MF: C16H19NO4
  • MW: 289.33
  • EINECS:
  • MDL Number:MFCD09953807
  • Synonyms:(1S,2S,3aR,12bS,12cR)-2,3,3a,4,5,7,12b,12c-Octahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol;1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,3,3a,4,5,7,12b,12c-octahydro-, (1S,2S,3aR,12bS,12cR)-;Dihydrolycorine,inhibit,Inhibitor
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :247 °C
Boiling point :460.5±45.0 °C(Predicted)
Density :1.48
solubility :Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form :Cryst.
pka :14.13±0.40(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Dihydrolycorine is a derivative of the alkaloid lycorine that has antihypertensive and neuroprotective activities. It inhibits methoxamine-induced contraction of isolated rabbit aortic rings and rat anococcygeus muscle with pA2 values of 5.93 and 6.35, respectively. Dihydrolycorine reduces mean arterial pressure (MAP) in anesthetized and conscious normotensive rats when administered at a dose of 80 mg/kg. It also reduces electrically or phenylephrine-induced hypertension in pithed rats. Dihydrolycorine reduces infarct size, cerebral edema, and myeloperoxidase activity in a rat model of focal cerebral ischemia-reperfusion injury when administered following reperfusion.

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Suppliers and manufacturers

career henan chemical co
Dihydrolycorine
₹9.80 /1KG
Dihydrolycorine CAS:6271-21-2
Chengdu GLP biotechnology Co Ltd
Chengdu Biopurify Phytochemicals Ltd.
Shaanxi Pioneer Biotech Co., Ltd .
Chongqing Chemdad Co., Ltd
CONIER CHEM AND PHARMA LIMITED
ANHUI WITOP BIOTECH CO., LTD
Baoji Guokang Bio-Technology Co., Ltd.
Dayang Chem (Hangzhou) Co.,Ltd.
LEAP CHEM CO., LTD.