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ChemicalBook > Product Catalogue >API >Synthetic Anti-infective Drugs >Antiviral drugs >Efavirenz

Efavirenz

Efavirenz Structure
  • ₹15403.98 - ₹62633.45
  • Product name: Efavirenz
  • CAS: 154598-52-4
  • MF: C14H9ClF3NO2
  • MW: 315.67
  • EINECS:620-492-6
  • MDL Number:MFCD05662344
  • Synonyms:(S)-6-Chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl) 2H-3,1-benzoxazin-2-one;(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one;Efavirenz (200 mg);(4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluoroMethyl)-2,4-dihydro-1H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoroMethyl)-, (4S)-;efavuirenz;Efavirenz solution;(S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-4-(TRIFLUOROMETHYL)-1H-BENZO[D][1,3]OXAZIN-2(4H)-ONE
4 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 500MG
  • 1ML
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0536
  • Product descriptionEfavirenz ≥98% (HPLC)
  • Packaging10MG
  • Price₹15403.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1284
  • Product descriptionEfavirenz Ready Made Solution 10?mg/mL in DMSO
  • Packaging1ML
  • Price₹17236.8
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2072
  • Product descriptionEfavirenz Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹29996.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0536
  • Product descriptionEfavirenz ≥98% (HPLC)
  • Packaging50MG
  • Price₹62633.45
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0536 Efavirenz ≥98% (HPLC) 10MG ₹15403.98 2022-06-14 Buy
Sigma-Aldrich(India) SML1284 Efavirenz Ready Made Solution 10?mg/mL in DMSO 1ML ₹17236.8 2022-06-14 Buy
Sigma-Aldrich(India) PHR2072 Efavirenz Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹29996.08 2022-06-14 Buy
Sigma-Aldrich(India) SML0536 Efavirenz ≥98% (HPLC) 50MG ₹62633.45 2022-06-14 Buy

Properties

Melting point :139-141°C
Boiling point :340.6±42.0 °C(Predicted)
alpha :D20 -84.7° (c = 0.005 g/ml in CH3Cl); D25 -94.1° (c = 0.300 in methanol)
Density :1.53±0.1 g/cm3(Predicted)
Flash point :2℃
storage temp. :-20°C
solubility :DMSO: soluble15mg/mL, clear
pka :10.2(at 25℃)
form :powder or crystals
color :white to beige
optical activity :[α]/D -90 to -100°, c = 1 in methanol
Water Solubility :8mg/L(temperature not stated)
λmax :247nm(MeOH)(lit.)
Merck :14,3521
BCS Class :4
EPA Substance Registry System :2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4S)- (154598-52-4)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are highly specific and potent allosteric inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Efavirenz is an NNRTI that prevents RNA plus-strand initiation with an IC50 value of 17 nM. Efavirenz also inhibits the late stages of HIV-1 replication by interfering with HIV-1 Gag-Pol polyprotein processing. It has been used in combination therapy with drugs directed at the treatment of opportunistic infections such as HIV and cancer.

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