GO 6976
- ₹22650 - ₹26950
- Product name: GO 6976
- CAS: 136194-77-9
- MF: C24H18N4O
- MW: 378.43
- EINECS:200-258-5
- MDL Number:MFCD00236434
- Synonyms:InSolution? G? 6976 ;5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;Go6976,5,6,7,13-Tetrahydro-13-Methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile;PD406976;12-(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO(2,3-A)PYRROLO(3,4-C)-CARBAZOLE;12-2(2-CYANOETHYL)-6,7,12,13-TETRAHYDRO-13-METHYL-5-OXO-5H-INDOLO[2,3-A]PYRROLO[3,4-C]CARBAZOLE;GO 6976;G6976
3 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 500μG
- 1MG
- 1ML
- ManufacturerSigma-Aldrich(India)
- Product number365250
- Product descriptionGö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo
- Packaging1MG
- Price₹22650
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number365253
- Product descriptionInSolution Gö 6976 - CAS 136194-77-9 - Calbiochem
- Packaging1ML
- Price₹25060
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number365250
- Product descriptionGö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo
- Packaging500μG
- Price₹26950
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 365250 | Gö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo | 1MG | ₹22650 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 365253 | InSolution Gö 6976 - CAS 136194-77-9 - Calbiochem | 1ML | ₹25060 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 365250 | Gö 6976 - CAS 136194-77-9 - Calbiochem G? 6976, CAS 136194-77-9, is a cell-permeable, reversible, and ATP-competitive inhibitor of PKC (IC?? = 7.9 nM for rat brain). Exhibits selectively fo | 500μG | ₹26950 | 2022-06-14 | Buy |
Properties
Melting point :>221°C (dec.)
Boiling point :652.3±55.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
form :Off-white solid
pka :14.39±0.20(Predicted)
color :White to Off-White
Boiling point :652.3±55.0 °C(Predicted)
Density :1.41±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,2-8°C
solubility :Acetonitrile (Very Slightly, Heated), DMSO (Slightly), Methanol (Very Slightly)
form :Off-white solid
pka :14.39±0.20(Predicted)
color :White to Off-White
Safety Information
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Description
G? 6976 is a nonglycosidic indolocarbazole that inhibits protein kinase C (PKC) with IC50 values of 2.3 and 6.2 nM for PKCα and PKCβ1, respectively. It does not inhibit the activity of PKCδ, PKCε, or PKCζ (IC50s > 3 μM), indicating a preference for the Ca2+-dependent subtypes, PKCα and PKCβ1. G? 6976 also inhibits the checkpoint kinases Chk1/2. It was shown to abrogate DNA damage-induced S- and G2-phase cell cycle arrest, leading to cytotoxicity in p53 mutant tumor cells.Related product price
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