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ChemicalBook > Product Catalogue >API >Hormones and the Endocrine System >Contraceptives >GOSSYPOL

GOSSYPOL

GOSSYPOL Structure
  • ₹20751.53 - ₹41568
  • Product name: GOSSYPOL
  • CAS: 303-45-7
  • MF: C30H30O8
  • MW: 518.55
  • EINECS:636-899-7
  • MDL Number:MFCD00017352
  • Synonyms:Gossypol from cotton seeds,2,2′-bis(8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene);Thespesin;GOSSYPOL;NSC 624336;NSC 56817;1,1',6,6',7,7'-HEXAHYDROXY-3,3'-DIMETHYL-5,5'-BIS(1-METHYLETHYL)-[2,2'-BINAPHTHALENE]-8,8'-DICARBOXALDEHYDE;2,2'-BIS[8-FORMYL-1,6,7-TRIHYDROXY-5-ISOPROPYL-3-METHYLNAPHTHALENE];2,2'-BIS[8-FORMYL-1,6,7-TRIHYDROXY-5-ISOPROPYL-3-METHYLNAPTHALENE]
2 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 100MG
  • 250MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberG8761
  • Product description(±)-Gossypol from cotton seeds ≥95% (HPLC)
  • Packaging100MG
  • Price₹20751.53
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberG8761
  • Product description(±)-Gossypol from cotton seeds ≥95% (HPLC)
  • Packaging250MG
  • Price₹41568
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) G8761 (±)-Gossypol from cotton seeds ≥95% (HPLC) 100MG ₹20751.53 2022-06-14 Buy
Sigma-Aldrich(India) G8761 (±)-Gossypol from cotton seeds ≥95% (HPLC) 250MG ₹41568 2022-06-14 Buy

Properties

Melting point :181-183 C
Boiling point :522.63°C (rough estimate)
Density :1.1912 (rough estimate)
refractive index :1.4900 (estimate)
storage temp. :2-8°C
solubility :≥25.95 mg/mL in DMSO; insoluble in H2O; ≥2.1 mg/mL in EtOH
form :Off-white to yellow solid.
pka :7.15±0.50(Predicted)
color :Light yellow to yellow
Water Solubility :Soluble in 100%ethanol (25 mg/ml), DMF (25 mg/ml), acetone, DMSO (25 mM), methanol (2 mg/ml), ether, chloroform, sodium carbonate, and dilute aqueous solutions of ammonia . Insoluble in water. Gossypol is a male antifertility agent with antispermatogenic activity and has been shown to contain antitumor, anitviral, and antioxidant properties.
InChIKey :QBKSWRVVCFFDOT-UHFFFAOYSA-N
LogP :5.419 (est)
CAS DataBase Reference :303-45-7
EPA Substance Registry System :[2,2'-Binaphthalene]-8,8'-dicarboxaldehyde, 1,1',6,6',7,7'-hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)- (303-45-7)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

Gossypol is a racemic mixture of natural polyphenols isolated from parts of the cotton plant (genus Gossypium). It causes infertility in a variety of cotton pests and spermatogenesis arrest in humans. Gossypol also has antimalarial properties, preventing the growth of P. falciparum at low micromolar concentrations. It inhibits aldose reductase (Ki = 0.5 μM). Gossypol also acts as an anticancer agent, inhibiting cell growth in various cancer cell lines, in part by blocking the anti-apoptotic functions of Bcl-2 and Bcl-xL, again at low micromolar concentrations.

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