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illudin S

illudin S Structure
  • ₹0
  • Product name: illudin S
  • CAS: 1149-99-1
  • MF: C15H20O4
  • MW: 264.32
  • EINECS:
  • MDL Number:MFCD00870487
  • Synonyms:illudin S;(2'S,3'R,6'R)-2',3'-Dihydro-3',6'-dihydroxy-2'-hydroxymethyl-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one;Illusin S;Lampterol;NSC-626369;(1R,2S,5R)-1,5-dihydroxy-2-(hydroxymethyl)-2,5,7-trimethylspiro[1H-indene-6,1'-cyclopropane]-4-one;Illudin;Illudine S
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :124-126℃
Boiling point :327.55°C (rough estimate)
Density :1.0583 (rough estimate)
refractive index :1.4300 (estimate)
storage temp. :-20°C, Inert atmosphere
solubility :DMSO (Slightly), Methanol (Slightly)
form :A light yellow solid
pka :12.50±0.70(Predicted)
color :Off-white to yellow

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

Illudins are fungal sesquiterpenes that, through their unique DNA alkylating actions, have anticancer potential. Illudin S is a cytotoxic illudin that is converted, intracellularly, to metabolites that cause a complete block of cell cycling at the G1-S phase interface, particularly in myeloid and T-lymphocyte leukemia cells (IC50 = 6-11 nM). T-lymphocyte leukemia CEM cells that are resistant to doxorubicin , epipodophyllotoxins, and 1-β-D-arabinofuranosylcytosine display only 2-fold increased resistance to illudin S. Illudin S metabolites induce DNA damage that is not repaired by the processes that counter conventional DNA alkylating agents.

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Suppliers and manufacturers

Shaanxi Dideu Medichem Co. Ltd
illudin S
₹0.00 /1KG
illudin S CAS:1149-99-1
CLEARSYNTH LABS LTD.
BOC Sciences
Fuxin Pharmaceutical
SHANGHAI T&W PHARMACEUTICAL CO., LTD.
TargetMol Chemicals Inc.
Shanghai Minbiotech Co., Ltd.
AFINE CHEMICALS LIMITED
Henan Alfa Chemical Co., Ltd
Nantong HI-FUTURE Biology Co., Ltd.