Name: JAK INHIBITOR I
Brand: chemicalbook
SKU: 457081-03-7

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JAK INHIBITOR I

₹16670
Product name: JAK INHIBITOR I
CAS: 457081-03-7
MF: C18H16FN3O
MW: 309.34
EINECS:
MDL Number:MFCD17019334
Synonyms:Merck-5;MERk-5;2-(tert-butyl)-9-fluoro-3H-benzo[h]iMidazo[4,5-f]isoquinolin-7(6H)-one;CMP 6;2-(1,1-Dimethylethyl)-9-fluoro-1,6-dihydro-7H-benz[h]imidazo[4,5-f]isoquinolin-7-one;Pyridone 6, >=98%;2-(1,1-DIMETHYLETHYL)-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F] ISOQUINOLIN-7-ONE;JAK INHIBITOR I

Price1 Properties Safety Information Description

1 prices

Selected condition：

Brand

Sigma-Aldrich(India)

Package

500μG

ManufacturerSigma-Aldrich(India)
Product number420097
Product descriptionInSolution JAK Inhibitor I - CAS 457081-03-7 - Calbiochem The InSolution JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is prima
Packaging500μG
Price₹16670
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	420097	InSolution JAK Inhibitor I - CAS 457081-03-7 - Calbiochem The InSolution JAK Inhibitor I, also referenced under CAS 457081-03-7, controls the biological activity of JAK. This small molecule/inhibitor is prima	500μG	₹16670	2022-06-14	Buy

Properties

Melting point :>178°C (dec.)
Boiling point :646.5±55.0 °C(Predicted)
Density :1.328
storage temp. :-20C
solubility :Soluble in DMSO (30 mg/ml)
form :Off-white solid
pka :11.35±0.20(Predicted)
color :Off-white
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. JAK1 mostly activates IL-6, whereas JAK1 and JAK3 trigger IL-2 and IL-4 and JAK1 and JAK2 stimulates IFN-γ. JAK Inhibitor I is a pyridine-containing tetracycle that interferes with JAK kinase activity by interacting within the ATP-binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively, while displaying signi?cantly weaker affinities (IC50s = 130 nM - > 10 μM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC50 values of 50-100 nM. In a mouse model of atopic dermatitis, JAK Inhibitor I, supplied at 2 mg encapsulated in a PLGA nanoparticle, was shown to suppress IFN-γ/STAT1, IL-2/STAT5, and IL-4/STAT6 signaling pathways.

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