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Lometrexol

Lometrexol Structure
  • ₹26184.9 - ₹115007.1
  • Product name: Lometrexol
  • CAS: 106400-81-1
  • MF: C21H25N5O6
  • MW: 443.45
  • EINECS:
  • MDL Number:
  • Synonyms:Lometrexol;(6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid;N-[4-[2-[[(6R)-2-Amino-3,4,5,6,7,8-hexahydro-4-oxopyrido[2,3-d]pyrimidin]-6-yl]ethyl]benzoyl]-L-glutamic acid;N-[4-[2-[[(R)-2-Amino-4-oxo-1,4,5,6,7,8-hexahydropyrido[2,3-d]pyrimidin]-6-yl]ethyl]benzoyl]-L-glutamic acid;L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)benzoyl)-;L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-D)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-;Lometrexolum;Lometrexolum [inn-latin]
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0040
  • Product descriptionLometrexol hydrate ≥95% (HPLC)
  • Packaging5MG
  • Price₹26184.9
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0040
  • Product descriptionLometrexol hydrate ≥95% (HPLC)
  • Packaging25MG
  • Price₹115007.1
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0040 Lometrexol hydrate ≥95% (HPLC) 5MG ₹26184.9 2022-06-14 Buy
Sigma-Aldrich(India) SML0040 Lometrexol hydrate ≥95% (HPLC) 25MG ₹115007.1 2022-06-14 Buy

Properties

Density :1.56±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥5mg/mL
pka :3.60±0.10(Predicted)
form :powder
color :white to light yellow
Stability :Hygroscopic

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Glycinamide ribonucleotide formyltransferase (GART) is a folate-dependent enzyme required for de novo purine synthesis. Lometrexol is a folate analog antimetabolite with antineoplastic activity. At nanomolar conentrations, it inhibits GART preventing de novo purine synthesis, inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD. TargetMol Chemicals Inc. Aladdin Scientific Beijing Shengke Boyuan Biotechnology Co., Ltd. Shanghai Hao Biological Technology Co., Ltd. Beijing Bolide Biotechnology Co., Ltd. Shanghai Yaoyun Biological Technology Co., Ltd. Shanghai Yubo Biotechnology Co., Ltd. Cayman Chemical Company Shenzhen Polymeri Biochemical Technology Co., Ltd.