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ChemicalBook > Product Catalogue >API >Urinary System Drugs >Diuretics Drugs >Metolazone

Metolazone

Metolazone Structure
  • ₹14624.58 - ₹63001.5
  • Product name: Metolazone
  • CAS: 17560-51-9
  • MF: C16H16ClN3O3S
  • MW: 365.83
  • EINECS:241-539-3
  • MDL Number:MFCD00069304
  • Synonyms:s720-22 ;7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide, SR-720-22, Diulo, Metenix, Mykrox, Oldren,;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- (9CI);6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl- (8CI);Normelan;Xuret;6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro- 2-methyl-3-(2-methylphenyl)-4-oxo-;METAZOLINE
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberM1195
  • Product descriptionMetolazone ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹14624.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM1195
  • Product descriptionMetolazone ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹63001.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) M1195 Metolazone ≥98% (HPLC), solid 5MG ₹14624.58 2022-06-14 Buy
Sigma-Aldrich(India) M1195 Metolazone ≥98% (HPLC), solid 25MG ₹63001.5 2022-06-14 Buy

Properties

Melting point :252-254°C
Boiling point :613.6±65.0 °C(Predicted)
Density :1.2895 (rough estimate)
refractive index :1.6100 (estimate)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :pKa 9.7 (Uncertain)
form :solid
color :white
Water Solubility :60.3mg/L(25 ºC)
Stability :Stable for 2 years as supplied. Solutions in DMSO may be stored desiccated at -20°C for up to 2 months.
InChIKey :AQCHWTWZEMGIFD-UHFFFAOYSA-N
CAS DataBase Reference :17560-51-9(CAS DataBase Reference)
NIST Chemistry Reference :Metolazone(17560-51-9)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Metolazone is a thiazide-like diuretic that targets the Na+-Cl- cotransporter responsible for salt reabsorption in the distal convoluted tubule of the kidney (IC50 = 0.3 μM in rat). It is also a potent inhibitor of human carbonic anhydrase isoforms VII, XII, and XIII (Kis = 2.1, 5.4, and 15 nM, respectively), which have crucial functions in renal physiology. Metolazone has been predominantly used in the treatment of congestive heart failure and high blood pressure.

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Suppliers and manufacturers

KARPSCHEM LABORATORIES Centaur Pharmaceuticals Pvt Ltd Pharmaffiliates Analytics and Synthetics P. Ltd SynZeal Research Pvt Ltd MSN LIFE SCIENCES PRIVATE LTD CENTAUR PHARMACEUTICALS PRIVATE LTD BIOPHORE INDIA PHARMACEUTICALS PVT LTD CLEARSYNTH LABS LTD.
Henan Tianfu Chemical Co.,Ltd.
CONIER CHEM AND PHARMA LIMITED