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MUSCIMOL

MUSCIMOL Structure
  • ₹10049.99 - ₹53269.83
  • Product name: MUSCIMOL
  • CAS: 2763-96-4
  • MF: C4H6N2O2
  • MW: 114.1
  • EINECS:220-430-4
  • MDL Number:MFCD00057894
  • Synonyms:5-(aminomethyl)isoxazol-3-ol hydrate ;MUSCIMOL CRYSTALLINE;Containsupto10%Ethanol;5-Aminomethyl-3-hydroxyisoxazole, 5-(Aminomethyl)-3(2H)-isoxazolone;Muscimol: (5-Aminomethyl-3-isoxyzole);5-Aminomethylisoxazol-3(2H)-one;Muscimol hydrate,98%;Muscimol hydrate5-(Aminomethyl)-3-isoxazolol
4 prices
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Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 10MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number5.06044
  • Product descriptionMuscimol - CAS 2763-96-4 - Calbiochem Muscimol is a constituent and psychoactive ingredient of the mushroom Amanita muscaria, that acts as a potent agonist of GABAA receptors.
  • Packaging1MG
  • Price₹10049.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM1523
  • Product descriptionMuscimol powder
  • Packaging5MG
  • Price₹17049.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM1523
  • Product descriptionMuscimol powder
  • Packaging10MG
  • Price₹24323.78
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM1523
  • Product descriptionMuscimol powder
  • Packaging25MG
  • Price₹53269.83
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 5.06044 Muscimol - CAS 2763-96-4 - Calbiochem Muscimol is a constituent and psychoactive ingredient of the mushroom Amanita muscaria, that acts as a potent agonist of GABAA receptors. 1MG ₹10049.99 2022-06-14 Buy
Sigma-Aldrich(India) M1523 Muscimol powder 5MG ₹17049.38 2022-06-14 Buy
Sigma-Aldrich(India) M1523 Muscimol powder 10MG ₹24323.78 2022-06-14 Buy
Sigma-Aldrich(India) M1523 Muscimol powder 25MG ₹53269.83 2022-06-14 Buy

Properties

Melting point :175-176°C
Boiling point :213.59°C (rough estimate)
Density :1.291
refractive index :1.4487 (estimate)
storage temp. :2-8°C
solubility :ethanol: 1 mg/mL
form :powder
pka :12.19±0.40(Predicted)
color :white to off-white
Water Solubility :Soluble in water (10 mg/ml), methanol, ethanol, 0.05 M HCl (20 mg/ml), DMSO (sparingly soluble), DMF (sparingly soluble), and PBS (pH 7.2) (10 mg/ml).
Merck :13,6336
BRN :1618960
Stability :Hygroscopic, Store in Freezer at -20°C
EPA Substance Registry System :5-(Aminomethyl)-3-isoxazolol (2763-96-4)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

The amino acid γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that acts through two families of heteromeric ligand-gated ion channels, GABAA and GABAC and a G protein-coupled receptor, GABAB. Muscimol is a full GABAA agonist and partial GABAC agonist. It binds GABAA on both high- and low-affinity sites (Kd = 10 and 270 nM, respectively), stimulating chloride efflux with an EC50 value of 200 nM. Benzodiazepines enhance the effects of muscimol via GABAA without altering its binding. Muscimol activates GABAC receptors with an EC50 value of 1.3 μM. It also acts as an inhibitor of GABAA uptake and a substrate for the GABA-metabolizing enzyme GABA transaminase. Muscimol impairs memory formation and retrieval in mice and attenuates airway constriction in guinea pigs in vivo.

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