NU7026
![]() |
- ₹27365.6 - ₹28240
- Product name: NU7026
- CAS: 154447-35-5
- MF: C17H15NO3
- MW: 281.31
- EINECS:
- MDL Number:MFCD06798345
- Synonyms:2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE;NU7026, >=98%;2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one;NU7026;LY293646; NU-7026;LY 293646;2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one;4H-Naphtho[1,2-b]pyran-4-one, 2-(4-morpholinyl)-;2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one NU7026
3 prices
Selected condition:
Brand
- Sigma-Aldrich
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich
- Product number260961
- Product descriptionDNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem The DNA-PK Inhibitor II, also referenced under CAS 154447-35-5, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl
- Packaging5MG
- Price₹28240
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberN1537
- Product descriptionNU7026 ≥98% (HPLC), solid
- Packaging5MG
- Price₹27365.6
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number260961
- Product descriptionDNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem The DNA-PK Inhibitor II, also referenced under CAS 154447-35-5, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily
- Packaging5MG
- Price₹28240
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich | 260961 | DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem The DNA-PK Inhibitor II, also referenced under CAS 154447-35-5, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appl | 5MG | ₹28240 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | N1537 | NU7026 ≥98% (HPLC), solid | 5MG | ₹27365.6 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 260961 | DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem The DNA-PK Inhibitor II, also referenced under CAS 154447-35-5, controls the biological activity of DNA-PK. This small molecule/inhibitor is primarily | 5MG | ₹28240 | 2022-06-14 | Buy |
Properties
Melting point :267-269 °C(Solv: methanol (67-56-1); water (7732-18-5))
Boiling point :459.9±45.0 °C(Predicted)
Density :1.330
storage temp. :2-8°C
solubility :DMSO: 3 mg/mL at 60 °C, soluble
form :solid
pka :0.49±0.20(Predicted)
color :tan
Boiling point :459.9±45.0 °C(Predicted)
Density :1.330
storage temp. :2-8°C
solubility :DMSO: 3 mg/mL at 60 °C, soluble
form :solid
pka :0.49±0.20(Predicted)
color :tan
Safety Information
Symbol(GHS): |
![]() |
||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Danger | ||||||||||||||
Hazard statements: |
|
||||||||||||||
Precautionary statements: |
|
Description
DNA-dependent protein kinase (DNA-PK) binds to strand breaks produced during normal cellular processes or in response to genotoxic stresses, such as ionizing radiation, targeting substrates that facilitate DNA repair. NU 7026 is a cell-permeable, potent, specific, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM). It poorly inhibits phosphioinositide 3 kinase (IC50 = 13 μM) and is inactive against ataxia telangiectasia mutated kinase, ATR, and poly (ADP-ribose) polymerase. NU 7026 impairs cellular DNA double strand break repair and decreases survival in cells exposed to ionizing radiation. It also potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. For example, it potentiates the growth inhibitory effects of mitoxantrone in K562 cells more than 10-fold.More related product prices
Olaparib ABT 737 KU-60019 1232410-49-9 KU-55933 KU57788(NU7441) 39236-46-9Related product price
- ABT 737
₹15910 - KU-60019
₹11431.2-46547.5 - 1232410-49-9
₹11431.2-46547.5