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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >OLIGOMYCIN

OLIGOMYCIN

OLIGOMYCIN Structure
  • ₹8724.95 - ₹232250.38
  • Product name: OLIGOMYCIN
  • CAS: 1404-19-9
  • MF: C135H220O33
  • MW: 2371.1715
  • EINECS:215-767-9
  • MDL Number:MFCD01779388
  • Synonyms:OLIGOMYCIN FROM STREPTOMYCES*DIASTATOCHR OMOGENE;OLIGOMYCIN, MIXTURE OF THE COMPONENTS A, B AND C;OLIGOMYCIN, MIXTURE OF A, B AND C;OligomycinABCcomplex;oligomycin from streptomyces diastatochromogenes;Nystatin dehydrate;OLIGOMYCIN, MIXTURE OF A, B AND C, FROM STREPTOMYCES DIASTATOCHROMOGENES;diastatochromogenes
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 10MG
  • 25MG
  • 100MG
  • 250MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberO4876
  • Product descriptionOligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC)
  • Packaging250MG
  • Price₹232250.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO4876
  • Product descriptionOligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC)
  • Packaging100MG
  • Price₹127085.5
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO4876
  • Product descriptionOligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC)
  • Packaging25MG
  • Price₹38699.38
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number495455
  • Product descriptionOligomycin - CAS 1404-19-9 - Calbiochem A mixture of A, B, and C isomers.
  • Packaging10MG
  • Price₹14310.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberO4876
  • Product descriptionOligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC)
  • Packaging5MG
  • Price₹8724.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) O4876 Oligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC) 250MG ₹232250.38 2022-06-14 Buy
Sigma-Aldrich(India) O4876 Oligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC) 100MG ₹127085.5 2022-06-14 Buy
Sigma-Aldrich(India) O4876 Oligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC) 25MG ₹38699.38 2022-06-14 Buy
Sigma-Aldrich(India) 495455 Oligomycin - CAS 1404-19-9 - Calbiochem A mixture of A, B, and C isomers. 10MG ₹14310.01 2022-06-14 Buy
Sigma-Aldrich(India) O4876 Oligomycin from Streptomyces diastatochromogenes ≥90% total oligomycins basis (HPLC) 5MG ₹8724.95 2022-06-14 Buy

Properties

Melting point :84-100 °C
Density :1.143 g/cm3
storage temp. :−20°C
solubility :Soluble in DMSO (up to 300 mg/ml) or in Ethanol (up to 200 mg/ml)
form :White solid
color :White
Water Solubility :Sparingly soluble in water. Soluble in DMSO (20mg/ml) and ethanol (30mg/ml) /n
BRN :7615308
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P330 Rinse mouth.

Description

Oligomycins are macrolides created by Streptomyces species that can be toxic to other organisms through their ability to inhibit mitochondrial membrane-bound ATP synthases. The mitochondrial F1FO ATP synthase can switch to an ATP hydrolase during ischemia, so that, under these conditions, inhibition by oligomycins will reduce ATP depletion rather than block ATP synthesis. Oligomycin complex is a mixture of oligomycins A , B , and C. Oligomycin A is a selective inhibitor of mitochondrial F1FO-ATP synthase that induces apoptosis in a variety of cell types (average GI50 = 270 nM). Oligomycin B is a nonselective inhibitor of ATP synthases. Oligomycin B (1-10 μM) can reduce the rate of ATP depletion in myocardial ischemia and decrease calcium-induced calcium release oscillation frequency of rat sensory neurons.

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