PF-01247324
![]() |
- ₹10825 - ₹43613.93
- Product name: PF-01247324
- CAS: 875051-72-2
- MF: C13H10Cl3N3O
- MW: 330.6
- EINECS:
- MDL Number:MFCD28156579
- Synonyms:2-PyridinecarboxaMide, 6-aMino-N-Methyl-5-(2,3,5-trichlorophenyl)-;6-amino-N-methyl-5-(2,3,5-trichlorophenyl)picolinamide;6-AMINO-5-(2,3,5-TRICHLORO-PHENYL)-PYRIDINE-2-CARBOXYLIC ACID METHYLAMIDE;PF-1247324;PF-01247324;6-AMINO-N-METHYL-5-(2,3,5-TRICHLOROPHENYL)PYRIDINE-2-CARBOXAMIDE;PF01247324;PF 01247324;133786
2 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0274
- Product descriptionPF-01247324 ≥98% (HPLC)
- Packaging5MG
- Price₹10825
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0274
- Product descriptionPF-01247324 ≥98% (HPLC)
- Packaging25MG
- Price₹43613.93
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PZ0274 | PF-01247324 ≥98% (HPLC) | 5MG | ₹10825 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PZ0274 | PF-01247324 ≥98% (HPLC) | 25MG | ₹43613.93 | 2022-06-14 | Buy |
Properties
Boiling point :477.7±45.0 °C(Predicted)
Density :1.460±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
pka :6.56±0.46(Predicted)
form :powder
color :white to beige
Density :1.460±0.06 g/cm3(Predicted)
storage temp. :room temp
solubility :DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:4): 0.2 mg/ml
pka :6.56±0.46(Predicted)
form :powder
color :white to beige
Safety Information
Symbol(GHS): |
![]() |
|||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Danger | |||||||||||||||||||||||||||||||||||
Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
PF-01247324 is a blocker of the tetrodotoxin-resistant (TTX-R) sodium channel Nav1.8 (IC50 = 0.19 μM for human Nav1.8). It is selective for Nav1.8 over Nav1.1, Nav1.2, Nav1.5, and Nav1.7 channels (IC50s = 13, 12.8, 9, and 19 μM, respectively) as well as ether-a-go-go (ERG) potassium channels (IC50 = 30 μM). PF-01247324 blocks Nav1.8 channels in a VSP-FRET assay using HEK293 cells (IC50 = 2.6 μM). In vivo, PF-01247324 (100 mg/kg) reduces phase 2 flinching in a rat model of formalin-induced persistent pain. It increases latency to lift the inflamed paw and latency to paw withdrawal in rat models of carrageenan-induced thermal hyperalgesia and mechanical hyperalgesia induced by complete Freund''s adjuvant (CFA), respectively.Related product price
- PNU 100480
₹11420.38-46515.03 - PF-06650833
₹10954.9 - PF-06282999
₹10684.28