PHENAMIL METHANESULFONATE
|
- ₹9883.23 - ₹38634.43
- Product name: PHENAMIL METHANESULFONATE
- CAS: 1161-94-0
- MF: C13H16ClN7O4S
- MW: 401.8
- EINECS:
- MDL Number:MFCD00274070
- Synonyms:MHPIZTURFVSLTJ-UHFFFAOYSA-N;2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-, methanesulfonate (1:1)
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberP203
- Product descriptionPhenamil methanesulfonate salt solid
- Packaging5MG
- Price₹9883.23
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP203
- Product descriptionPhenamil methanesulfonate salt solid
- Packaging25MG
- Price₹38634.43
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | P203 | Phenamil methanesulfonate salt solid | 5MG | ₹9883.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P203 | Phenamil methanesulfonate salt solid | 25MG | ₹38634.43 | 2022-06-14 | Buy |
Properties
storage temp. :2-8°C
solubility :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL
form :solid
color :yellow
CAS DataBase Reference :1161-94-0
solubility :45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble2.5mg/mL
form :solid
color :yellow
CAS DataBase Reference :1161-94-0
Safety Information
| Symbol(GHS): | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal word: | ||||||||
| Hazard statements: |
|
|||||||
| Precautionary statements: |
|
Description
Transient receptor potential polycystin-L (TRPP3) is a member of the TRP superfamily of cation channels that is localized to a subset of taste receptor cells in the tongue and to neurons surrounding the central canal of the spinal cord. Phenamil is a second generation analog of amiloride (hydrochloride) , the prototypical epithelial sodium channel (ENaC) blocker that inhibits TRPP3-mediated Ca2+-activated currents with an IC50 value of 0.14 μM. It is also known to inhibit ENaC (IC50 = 10 nM). ENaC blockers such as phenamil have been proposed as a therapy to restore mucus clearance in cystic fibrosis airways. Phenamil inhibits active sodium transport of human and ovine bronchial epithelial cells with IC50 values of 75 and 116 nM, respectively.More related product prices
2-Amino-5-chloropyrazineRelated product price
- 1428-95-1
₹10402.83-33514.2 - 2-Amino-5-chloropyrazine
₹3200-12500 - PHENAMIL METHANESULFONATE
₹9883.23-38634.43