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ChemicalBook > Product Catalogue >API >Circulatory system drugs >Antiarrhythmics Drugs >Quinidine

Quinidine

Quinidine Structure
  • ₹3900 - ₹26997.55
  • Product name: Quinidine
  • CAS: 56-54-2
  • MF: C20H24N2O2
  • MW: 324.42
  • EINECS:200-279-0
  • MDL Number:MFCD00135581
  • Synonyms:(8R,9S)-6'-Methoxycinchonan-9-ol;CONCHININE;CONQUININE;B-QUININE;(+)-QUINIDINE;QUINIDINE;(+)-QUINDINE;PITAYINE
6 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5G
  • 10G
  • 25G
  • 50G
  • ManufacturerTCI Chemicals (India)
  • Product numberQ0006
  • Product descriptionQuinidine
  • Packaging5G
  • Price₹3900
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberQ0006
  • Product descriptionQuinidine
  • Packaging25G
  • Price₹11000
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberQ3625
  • Product descriptionQuinidine anhydrous
  • Packaging5G
  • Price₹4373.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number22600
  • Product descriptionQuinidine crystallized, ≥98.0% (dried material, NT)
  • Packaging10G
  • Price₹8703.3
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberQ3625
  • Product descriptionQuinidine anhydrous
  • Packaging25G
  • Price₹16573.08
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number22600
  • Product descriptionQuinidine crystallized, ≥98.0% (dried material, NT)
  • Packaging50G
  • Price₹26997.55
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) Q0006 Quinidine 5G ₹3900 2022-05-26 Buy
TCI Chemicals (India) Q0006 Quinidine 25G ₹11000 2022-05-26 Buy
Sigma-Aldrich(India) Q3625 Quinidine anhydrous 5G ₹4373.3 2022-06-14 Buy
Sigma-Aldrich(India) 22600 Quinidine crystallized, ≥98.0% (dried material, NT) 10G ₹8703.3 2022-06-14 Buy
Sigma-Aldrich(India) Q3625 Quinidine anhydrous 25G ₹16573.08 2022-06-14 Buy
Sigma-Aldrich(India) 22600 Quinidine crystallized, ≥98.0% (dried material, NT) 50G ₹26997.55 2022-06-14 Buy

Properties

Melting point :168-172 °C(lit.)
alpha :256 º (c=1, EtOH)
Boiling point :462.75°C (rough estimate)
Density :1.1294 (rough estimate)
refractive index :1.5700 (estimate)
storage temp. :Keep in dark place,Sealed in dry,2-8°C
solubility :insoluble in H2O; ≥10.32 mg/mL in EtOH with ultrasonic; ≥11.95 mg/mL in DMSO
form :Powder
pka :5.4, 10.0(at 20℃)
color :White to off-white
optical activity :[α]20/D +265±5°, c = 0.8% in ethanol (dry matter)
Water Solubility :0.05 g/100 mL (20 ºC)
Sensitive :Light Sensitive
Merck :14,8060
BRN :91866
BCS Class :1
Stability :Stable. Incompatible with strong oxidizing agents.
LogP :3.440
CAS DataBase Reference :56-54-2(CAS DataBase Reference)
NIST Chemistry Reference :Quinine(56-54-2)
EPA Substance Registry System :Quinidine (56-54-2)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P352 IF ON SKIN: wash with plenty of soap and water.

Description

Quinidine is a commonly used class I antiarrhythmic drug. It is a stereoisomer of quinine, originally derived from the bark of the cinchona tree. It exerts its antiarrhythmic effects on the heart by interacting with the electrophysiology mechanisms that cause arrhythmias to modify the abnormalities in impulse initiation and conduction. Quinidine depresses normal automaticity in cardiac fibers that may act as ectopic pacemakers causing arrhythmias. Quinidine also blocks the slowly inactivating, tetrodotoxin-sensitive Na current, the slow inward calcium current (ICa), the rapid (IKr) and slow (IKs) components of the delayed potassium rectifier current, the inward potassium rectifier current (IKI), the ATP-sensitive potassium channel (IKATP) and Ito.

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