Welcome to chemicalbook!
China english Japan Germany India
400-158-6606
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
Structured search
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
head sculpture My chemicalbook

Welcome back!

RFQ
skype
MY Account
Top
ChemicalBook > Product Catalogue >API >Respiratory Drugs >Asthma drugs >Roflumilast

Roflumilast

Roflumilast Structure
  • ₹7079.55 - ₹28740.38
  • Product name: Roflumilast
  • CAS: 162401-32-3
  • MF: C17H14Cl2F2N2O3
  • MW: 403.21
  • EINECS:685-382-2
  • MDL Number:MFCD00938270
  • Synonyms:ROFLUMILAST;3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy)benzamide;B 9302-107;BY 217;BYK 20869;Daxas;Roflumilast / 3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide;3-(Cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl)-4-(difluoromethoxy)benzamide
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 10MG
  • 50MG
  • 250MG
  • 1G
  • ManufacturerTCI Chemicals (India)
  • Product numberR0193
  • Product descriptionRoflumilast
  • Packaging250MG
  • Price₹9700
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberR0193
  • Product descriptionRoflumilast
  • Packaging1G
  • Price₹19100
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1099
  • Product descriptionRoflumilast ≥98% (HPLC)
  • Packaging10MG
  • Price₹7079.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML1099
  • Product descriptionRoflumilast ≥98% (HPLC)
  • Packaging50MG
  • Price₹28740.38
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) R0193 Roflumilast 250MG ₹9700 2022-05-26 Buy
TCI Chemicals (India) R0193 Roflumilast 1G ₹19100 2022-05-26 Buy
Sigma-Aldrich(India) SML1099 Roflumilast ≥98% (HPLC) 10MG ₹7079.55 2022-06-14 Buy
Sigma-Aldrich(India) SML1099 Roflumilast ≥98% (HPLC) 50MG ₹28740.38 2022-06-14 Buy

Properties

Melting point :158°C
Boiling point :430.6±45.0 °C(Predicted)
Density :1.471±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble20mg/mL, clear
pka :9.89±0.70(Predicted)
form :powder
color :white to beige
Merck :14,8249
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)
InChIKey :MNDBXUUTURYVHR-UHFFFAOYSA-N
SMILES :C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1
CAS DataBase Reference :162401-32-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Type 4 cyclic nucleotide phosphodiesterase (PDE4) isoforms selectively inactivate the second messenger cAMP by hydrolyzing the phosphodiester bond, producing AMP. Roflumilast is a potent, cell-permeable inhibitor of PDE4 (IC50 = < 1 nM for both human PDE4B and PDE4D). It is selective for PDE4, with IC50 values against other PDE forms being greater than 10 μM. Roflumilast demonstrates good bioavailability and has applications in respiratory diseases, including asthma and chronic obstructive pulmonary disease.

More related product prices

2-Chloro-5-chloromethylpyridine Fleroxacin Clopyralid Benzamide p-Aminobenzamide Ezetimibe 162401-62-9 benzaMide, N-(3,5-dichloro-4-pyridinyl)-4-(difluoroMethoxy)-3-hydroxy- 22889-78-7 RofluMilast related substance RofluMilast related substance RofluMilast N-Oxide N-(3,5-Dichloro-4-pyridinyl)-3,4-bis(difluoroMethoxy)benzaMide BenzaMide, 3,4-bis(cyclopropylMethoxy)-N-(3,5-dichloro-4-pyridinyl)- RofluMilast related substance N-(3-Chloropyridin-4-yl)-3-(cyclopropylMethoxy)-4-(difluoroMethoxy)benzaMide

Related product price

Suppliers and manufacturers

Micro Orgo Chem Nivika Chemo Pharma Pvt Ltd Glenmark Pharmaceuticals Limited Hetero Drugs Limited Bioaltus Laboratories Pvt Ltd Ralington Pharma Navone Specialties (OPC) Pvt Ltd CLEARSYNTH LABS LTD. A.J Chemicals TCI Chemicals (India) Pvt. Ltd.