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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Metabolism >Retinoid Receptor agonists >Tamibarotene

Tamibarotene

Tamibarotene Structure
  • ₹10857.48 - ₹39771.05
  • Product name: Tamibarotene
  • CAS: 94497-51-5
  • MF: C22H25NO3
  • MW: 351.44
  • EINECS:1806241-263-5
  • MDL Number:MFCD00866188
  • Synonyms:AM80;Tamibarotene;4-[(5,5,8,8-Tetramethyl-6,7-dihydronaphthalen-2-yl)carbamoyl]benzoic acid;4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoic Acid;Am 80 (pharmaceutical);Amnolake;NSC 608000;Retinoid AM 80
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberT3205
  • Product descriptionTamibarotene ≥98% (HPLC)
  • Packaging5MG
  • Price₹10857.48
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT3205
  • Product descriptionTamibarotene ≥98% (HPLC)
  • Packaging25MG
  • Price₹39771.05
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T3205 Tamibarotene ≥98% (HPLC) 5MG ₹10857.48 2022-06-14 Buy
Sigma-Aldrich(India) T3205 Tamibarotene ≥98% (HPLC) 25MG ₹39771.05 2022-06-14 Buy

Properties

Melting point :231-232°C
Boiling point :449.6±45.0 °C(Predicted)
Density :1.154±0.06 g/cm3(Predicted)
RTECS :DH6940000
storage temp. :room temp
solubility :Soluble to 50 mM in DMSO
form :powder
pka :3.83±0.10(Predicted)
color :white to off-white

Safety Information

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Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
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Description

Tamibarotene (brand name: Amnolake) is a kind of orally administrated synthetic retinoid. It is used to overcome the all- trans retinoid acid (ATRA) resistance, having potential antineoplastic activity against the acute promyelocytic leukaemia (APL). It can also be used for the treatment of Alzheimer's disease, multiple myeloma and Crohn's disease. Tamibarotene takes effect through directly acting as the specific agonist for retinoid acid receptor alpha/beta, and potentially binding to the retinoid X receptors (RXR). Compared to the ATRA, Tamibarotene is chemically more stable and much more potent as an inducer of differentiation and apoptosis in promyelocytic leukemia cells.

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