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ChemicalBook > Product Catalogue >API >Antibiotics >Amphenicols Drugs >Thiamphenicol

Thiamphenicol

Thiamphenicol Structure
  • ₹1680 - ₹45010.35
  • Product name: Thiamphenicol
  • CAS: 15318-45-3
  • MF: C12H15Cl2NO5S
  • MW: 356.22
  • EINECS:239-355-3
  • MDL Number:MFCD00467983
  • Synonyms:THIAMPHENICOL;methylsulfonyl chloramphenicol;D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-P-(METHYL-SULFONYL)PHENETHYL]ACETAMIDE;Acetamide, 2,2-dichloro-N-(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-4-(methylsulfonyl)phenylethyl-;d-threo-2,2-dichloro-n-(β-hydroxy-α-[hydroxymethyl]-4-[methylsulfonyl]phenethyl)acetamide;Acetamide, 2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]- (9CI);Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-, [R-(R*,R*)]-;Acetamide, 2,2-dichloro-N-[b-hydroxy-a-(hydroxymethyl)-p-(methylsulfonyl)phenethyl]-, D-threo-(+)- (8CI)
8 prices
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Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • SRL

Package

  • 100MG
  • 1G
  • 5G
  • 25G
  • 1Gms
  • 5Gms
  • ManufacturerTCI Chemicals (India)
  • Product numberT2802
  • Product descriptionThiamphenicol
  • Packaging5G
  • Price₹6100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberT2802
  • Product descriptionThiamphenicol
  • Packaging25G
  • Price₹6800
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT0261
  • Product descriptionThiamphenicol
  • Packaging1G
  • Price₹5704.78
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number16715
  • Product descriptionThiamphenicol analytical standard
  • Packaging100MG
  • Price₹5986.23
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT0261
  • Product descriptionThiamphenicol
  • Packaging5G
  • Price₹11258
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT0261
  • Product descriptionThiamphenicol
  • Packaging25G
  • Price₹45010.35
  • Updated2022-06-14
  • Buy
  • ManufacturerSRL
  • Product number79903
  • Product descriptionThiamphenicol (TMP), 98%
  • Packaging1Gms
  • Price₹1680
  • Updated2022-05-26
  • Buy
  • ManufacturerSRL
  • Product number79903
  • Product descriptionThiamphenicol (TMP), 98%
  • Packaging5Gms
  • Price₹4730
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) T2802 Thiamphenicol 5G ₹6100 2022-05-26 Buy
TCI Chemicals (India) T2802 Thiamphenicol 25G ₹6800 2022-05-26 Buy
Sigma-Aldrich(India) T0261 Thiamphenicol 1G ₹5704.78 2022-06-14 Buy
Sigma-Aldrich(India) 16715 Thiamphenicol analytical standard 100MG ₹5986.23 2022-06-14 Buy
Sigma-Aldrich(India) T0261 Thiamphenicol 5G ₹11258 2022-06-14 Buy
Sigma-Aldrich(India) T0261 Thiamphenicol 25G ₹45010.35 2022-06-14 Buy
SRL 79903 Thiamphenicol (TMP), 98% 1Gms ₹1680 2022-05-26 Buy
SRL 79903 Thiamphenicol (TMP), 98% 5Gms ₹4730 2022-05-26 Buy

Properties

Melting point :163-166 °C
alpha :D25 +12.9° (ethanol)
Density :1.3281 (rough estimate)
refractive index :1.6000 (estimate)
storage temp. :Sealed in dry,Room Temperature
solubility :ethanol: 50 mg/mL, clear, colorless
form :powder
Boiling point :695.9±55.0 °C(Predicted)
pka :11.05±0.46(Predicted)
color :white to off-white
Water Solubility :Soluble in acetonitrile or DMF. Slightly soluble in water
Merck :14,9301
BRN :2819542
InChIKey :OTVAEFIXJLOWRX-NXEZZACHSA-N
CAS DataBase Reference :15318-45-3
EPA Substance Registry System :Thiamphenicol (15318-45-3)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Thiamphenicol is a broad-spectrum antibiotic chloramphenicol, which is more effective to the gram-negative bacteria than the gram-positive bacteria. At room temperature, it is a white to off-white crystalline powder or crystal, which can be quickly and completely absorped by oral adminstration, as well as it is excreted mainly in the prototype from the urine for metabolism. It is clinically applied for the treatment of respiratory, urinary tract, liver and gallbladder, typhoid and other intestinal surgery, gynecology and ENT infections. Especially in the mild infections it is more effective. It has the similar chemical structure with the chloramphenicol. Its methyl sulfone substituted the nitro of chloramphenicol, which reduced its toxicity, and in vivo its antibacterial activity is 2.5-5 times stronger than chloramphenicol. For gram-positive bacteria, such as streptococcus pneumoniae and hemolytic streptococcus, it has very strong antibacterial effect, while for gram-negative bacteria, such as Neisseria gonorrhoeae, meningococcus, lung Bacteroides, E. coli, Vibrio cholerae, Shigella and influenza bacillus, it also has strong antibacterial effect. For anaerobic bacteria, Rickettsia and amoeba, it has antibacterial effect in some extent. It has the same antimicrobial mechanism with chloramphenicol, which mainly inhibits the synthesis of bacterial protein. This drug is absorped quickly by oral administration, which reaches peak blood concentration within two hours. Its half-life is 5 hours, that is more longer than chloramphenicol. The bacteria have complete cross resistance to it and chloramphenicol, while the bacteria have some cross-resistance phenomenon to it and tetracycline.
Thiamphenicol also has strong immunosuppressive effects, which is an excellent immunosuppressant. Its mechanism of action have significantly different with other immunosuppressive agents. The immunosuppressive effect is several times higher than the chloramphenicol. It can be as the effective extender for transplantation reaction and surgically allogeneic transplantation.

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