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U-46619

U-46619 Structure
  • ₹34261.13 - ₹189718.95
  • Product name: U-46619
  • CAS: 56985-40-1
  • MF: C21H34O4
  • MW: 350.49
  • EINECS:
  • MDL Number:MFCD00135238
  • Synonyms:9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO;9,11-DIDEOXY-11A,9A-EPOXYMETHANO-*PROSTA GLANDIN F2A;9,11-dideoxy-11α,9α-epoxymethanoprostaglandin f2α;9,11-dideoxy-11alpha,9alpha-epoxymethanoprostaglandin F2a;(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2 -oxabicyclo[2.2.1]hept-5-yl]-5-heptenoic acid;(5Z)-7-[(1R,4S)-6β-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]heptan-5α-yl]-5-heptenoic acid;(Z)-7-[(1R,4S)-6β-[(E,S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5α-yl]-5-heptenoic acid;11α,9α-Epoxymethanoprostaglandin H2
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • 10MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberD8174
  • Product description9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10?mg/mL in methyl acetate
  • Packaging1MG
  • Price₹34261.13
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD8174
  • Product description9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10?mg/mL in methyl acetate
  • Packaging5MG
  • Price₹107286.58
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberD8174
  • Product description9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10?mg/mL in methyl acetate
  • Packaging10MG
  • Price₹189718.95
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) D8174 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10?mg/mL in methyl acetate 1MG ₹34261.13 2022-06-14 Buy
Sigma-Aldrich(India) D8174 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10?mg/mL in methyl acetate 5MG ₹107286.58 2022-06-14 Buy
Sigma-Aldrich(India) D8174 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10?mg/mL in methyl acetate 10MG ₹189718.95 2022-06-14 Buy

Properties

Boiling point :519.7±30.0 °C(Predicted)
Density :1.092±0.06 g/cm3(Predicted)
Flash point :-10 °C
storage temp. :-20°C
solubility :≥100 mg/mL in DMSO, ≥100 mg/mL in Ethanol, ≥100 mg/mL in DMF, ≥2 mg/mL in PBS pH 7.2
pka :4.76±0.10(Predicted)
form :solution
color :Colorless to light yellow
BRN :4267334

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

U-46619 is a stable analog of the endoperoxide prostaglandin H2, and a TP receptor agonist. It exhibits properties similar to thromboxane A2, causing platelet shape change and aggregation, and contraction of vascular smooth muscle. Mean EC50 values for shape change in human, rat, and rabbit platelets are 4.8, 6.0, and 7.3 nM respectively, and for aggregation are 82, 145, and 65 nM, respectively.

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